Preconditioning with levosimendan prevents contractile dysfunction due to H2O2-induced oxidative stress in human myocardium

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dc.contributor.authorSahin, Ayse Saide
dc.contributor.authorGoemues, Niyazi
dc.contributor.authorDuman, Ates
dc.date.accessioned2020-03-26T17:17:55Z
dc.date.available2020-03-26T17:17:55Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe studied the inotropic and possible antioxidant effects of levosimendan in human atrial strips, before and after induction of oxidative stress induced by H2O2. Levosimendan (10(-9) to 10(-6) M) increased contractions induced by electrical stimulation (ES) in human atrial strips. The maximal positive inotropic effect of levosimendan was 145.6 +/- 4.6% of predrug values. H2O2 (10-6 to 10(-3) M) significantly reduced contractions induced by ES. The maximum inhibition by H2O2 on the ES induced contraction was 47.2 +/- 3.5%. Levosimendan significantly increased the isometric contractions induced by ES when compared with the values obtained in the presence of 10(-5) M H2O2 by 89.0 +/- 4.7%, 98.9 +/- 3.4%, and 111.2 +/- 3.7% at 10(-8), 10(-7), and 10(-6) M concentrations, respectively. In concentrations of 10(-7) and 10(-6) M levosimendan, the maximum responses to ES increased when compared with the values obtained in the presence of 10(-3) M H2O2 by 87.1 +/- 3.6% and 95.1 +/- 5.3%, respectively. The cumulatively applied H2O2 (10(-6)-10(-3) M) did not change the positive inotropic response to levosimendan. In conclusion, levosimendan reverses the myocardial dysfunction induced by oxidative stress in human right atrial strips. Levosimendan prevents myocardial dysfunction if administered before oxidative stress.en_US
dc.identifier.endpage423en_US
dc.identifier.issn0160-2446en_US
dc.identifier.issue4en_US
dc.identifier.pmid18049310en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage419en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21540
dc.identifier.volume50en_US
dc.identifier.wosWOS:000250415100011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofJOURNAL OF CARDIOVASCULAR PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthuman myocardiumen_US
dc.subjectlevosimendanen_US
dc.subjectoxidative stressen_US
dc.titlePreconditioning with levosimendan prevents contractile dysfunction due to H2O2-induced oxidative stress in human myocardiumen_US
dc.typeArticleen_US

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