SIMULTANEOUS AND ACCURATE DETERMINATION OF WATER- AND FAT-SOLUBLE VITAMINS IN MULTIVITAMIN TABLETS BY USING AN RP-HPLC METHOD
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SOC BRASILEIRA QUIMICA
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In the present study, a reversed-phase high-performance liquid chromatographic (RP-HPLC) procedure was developed and validated for the simultaneous determination of seven water-soluble vitamins (thiamine, riboflavin, niacin, cyanocobalamin, ascorbic acid, folic acid, and p-aminobenzoic acid) and four fat-soluble vitamins (retinol acetate, cholecalciferol, alpha-tocopherol, and phytonadione) in multivitamin tablets. The linearity of the method was excellent (R-2 > 0.999) over the concentration range of 10-500 ng mL(-1). The statistical evaluation of the method was carried out by performing the intra-and inter-day precision. The accuracy of the method was tested by measuring the average recovery; values ranged between 87.4% and 98.5% and were acceptable quantitative results that corresponded with the label claims.
Açıklama
Anahtar Kelimeler
simultaneous determination, water-soluble and fat-soluble vitamins, RP-HPLC
Kaynak
QUIMICA NOVA
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
36
Sayı
7
