SIMULTANEOUS AND ACCURATE DETERMINATION OF WATER- AND FAT-SOLUBLE VITAMINS IN MULTIVITAMIN TABLETS BY USING AN RP-HPLC METHOD

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dc.contributor.authorKucukkolbasi, Semahat
dc.contributor.authorBilber, Onur
dc.contributor.authorAyyildiz, H. Filiz
dc.contributor.authorKara, Huseyin
dc.date.accessioned2020-03-26T18:43:22Z
dc.date.available2020-03-26T18:43:22Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the present study, a reversed-phase high-performance liquid chromatographic (RP-HPLC) procedure was developed and validated for the simultaneous determination of seven water-soluble vitamins (thiamine, riboflavin, niacin, cyanocobalamin, ascorbic acid, folic acid, and p-aminobenzoic acid) and four fat-soluble vitamins (retinol acetate, cholecalciferol, alpha-tocopherol, and phytonadione) in multivitamin tablets. The linearity of the method was excellent (R-2 > 0.999) over the concentration range of 10-500 ng mL(-1). The statistical evaluation of the method was carried out by performing the intra-and inter-day precision. The accuracy of the method was tested by measuring the average recovery; values ranged between 87.4% and 98.5% and were acceptable quantitative results that corresponded with the label claims.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [SU-BAP 09201147]en_US
dc.description.sponsorshipThis study, as part of an M.Sc. Thesis, was supported by the Selcuk University Coordinators of Scientific Research with project number SU-BAP 09201147. The authors wish to thank the principal coordinator of the Selcuk University and Scientific Research Project.en_US
dc.identifier.doi10.1590/S0100-40422013000700020en_US
dc.identifier.endpage1051en_US
dc.identifier.issn0100-4042en_US
dc.identifier.issn1678-7064en_US
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1044en_US
dc.identifier.urihttps://dx.doi.org/10.1590/S0100-40422013000700020
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29818
dc.identifier.volume36en_US
dc.identifier.wosWOS:000324596200021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSOC BRASILEIRA QUIMICAen_US
dc.relation.ispartofQUIMICA NOVAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectsimultaneous determinationen_US
dc.subjectwater-soluble and fat-soluble vitaminsen_US
dc.subjectRP-HPLCen_US
dc.titleSIMULTANEOUS AND ACCURATE DETERMINATION OF WATER- AND FAT-SOLUBLE VITAMINS IN MULTIVITAMIN TABLETS BY USING AN RP-HPLC METHODen_US
dc.typeArticleen_US

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