Quantitative assessment of the effect of fasting on macular microcirculation: An optical coherence tomography angiography study

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dc.contributor.authorKaraküçük, Yasin
dc.contributor.authorBeyoğlu, Abdullah
dc.contributor.authorÇömez, Ayşegül
dc.date.accessioned2020-03-26T20:20:00Z
dc.date.available2020-03-26T20:20:00Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: To analyse the effect of fasting on the retinal vascular plexus and choriocapillaris structures in healthy subjects via Optical Coherence Tomography Angiography (OCTA). Methods: In this prospective study, OCTA scans of 98 eyes in 49 healthy subjects were compared in fasting and non-fasting period. All cases had a full ophthalmological examination, with OCTA parameters measured, including superficial flow area (SCP) (mm2), deep flow area (DCP) (mm2), choriocapillaris flow area (CC) (mm2), superficial and deep vascular density (SVD and DVD, respectively) (%), superficial foveal avascular zone area (FAZs) (mm2), deep foveal avascular zone area (FAZd) (mm2), subfoveal choroidal thickness (SFCT) (?m) and central macular thickness (CMT) (?m). Results: The mean SCP, DCP and CC flow area values were induced to be significantly lower in a fasting than a non-fasting period (p<0.001, p<0.001, p=0.049, respectively). The mean VD in a fasting period was statistically significantly lower than in a non-fasting period at the SCP level (p=0.009). No statistically significant difference was found between the two periods in respect to DVD, FAZd and CMT (p=0.068, p=0.653 and p=0.531, respectively); however, FAZs were significantly lower in a non-fasting than fasting period (p=0.038). The SFCT was determined to be statistically significant and thicker during a fasting period (p<0.001). Conclusion: The current study documented several physiological changes in a fasting period, such as changes in SCP, DCP, CC flow, SVD and DVD, via OCTA. © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.en_US
dc.identifier.citationKaraküçük, Y., Beyoğlu, A., Çömez, A. (2019). Quantitative Assessment of the Effect of Fasting on Macular Microcirculation: An Optical Coherence Tomography Angiography Study. British Journal of Ophthalmology, 104,(8),1098-1102.
dc.identifier.doi10.1136/bjophthalmol-2019-314962en_US
dc.identifier.issn0007-1161en_US
dc.identifier.pmid31662312en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1136/bjophthalmol-2019-314962
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38471
dc.identifier.wosWOS:000602289600013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaraküçük, Yasin
dc.language.isoenen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.ispartofBritish Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectfastingen_US
dc.subjectfoveal avascular zone (FAZ)en_US
dc.subjectmacular circulationen_US
dc.subjectoptical coherence tomography angiography (OCTA)en_US
dc.subjectvessel densityen_US
dc.titleQuantitative assessment of the effect of fasting on macular microcirculation: An optical coherence tomography angiography studyen_US
dc.typeArticleen_US

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