Plasma Fatty Acid Composition in Continuous Ambulatory Peritoneal Dialysis Patients: An Increased Omega-6/Omega-3 Ratio and Deficiency of Essential Fatty Acids

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dc.contributor.authorYerlikaya, Fatma Humeyra
dc.contributor.authorMehmetoglu, Idris
dc.contributor.authorKurban, Sevil
dc.contributor.authorTonbul, Zeki
dc.date.accessioned2020-03-26T18:15:38Z
dc.date.available2020-03-26T18:15:38Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPatients with end-stage renal disease, including those treated with peritoneal dialysis, have a high risk for death, particularly from cardiovascular causes. Plasma fatty acid (FA) composition is used as an indicator of disease risk, because its alteration has been related to metabolic disease and cardiovascular disease. For this purpose, we have measured plasma FA composition in continuous ambulatory peritoneal dialysis (CAPD) patients and compared them with those of healthy subjects. This study was performed on 51 (21 M, 30 F) CAPD patients at least 6 months under dialysis, aged 20-75 years (mean 47.81 +/- 11.8 years) and 45 (25 M, 20 F) healthy control subjects aged 20-60 years (mean 38.62 +/- 12.9 years). Plasma 10-cis-pentadecanoic acid, 10-cis-heptadecanoic acid, heneicosanoic acid, tricosanoic acid, nervonic acid, saturated fatty acid, and monounsaturated FA levels and delta 9 desaturase activity were significantly higher whereas linoleic acid, linolenic acid, 11,14-eicosedienoic acid, arachidonic acid, docosahexaenoic acid, and omega-3 FA levels were significantly lower in the CAPD group than those in the healthy group. Our results show that there are FA abnormalities and especially a depletion in essential FA levels and a high level of omega-6/omega-3 ratio in CAPD patients, the underlying mechanism of which is not known and needs to be investigated. Therefore, we believe that essential FA supplementation should be encouraged for CAPD patients.en_US
dc.identifier.doi10.3109/0886022X.2011.601831en_US
dc.identifier.endpage823en_US
dc.identifier.issn0886-022Xen_US
dc.identifier.issn1525-6049en_US
dc.identifier.issue8en_US
dc.identifier.pmid21793790en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage819en_US
dc.identifier.urihttps://dx.doi.org/10.3109/0886022X.2011.601831
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26721
dc.identifier.volume33en_US
dc.identifier.wosWOS:000294118700013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofRENAL FAILUREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectessential fatty acidsen_US
dc.subjectomega-6 fatty acidsen_US
dc.subjectomega-3 fatty acidsen_US
dc.subjectperitoneal dialysisen_US
dc.subjectelongase activityen_US
dc.subjectdesaturase activityen_US
dc.titlePlasma Fatty Acid Composition in Continuous Ambulatory Peritoneal Dialysis Patients: An Increased Omega-6/Omega-3 Ratio and Deficiency of Essential Fatty Acidsen_US
dc.typeArticleen_US

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