5-Hydroxytryptamine-Induced Contraction of Human Isolated Umbilical Artery and Its Dependence on Cellular and Extracellular Ca++

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dc.contributor.authorDoğan, N.
dc.contributor.authorÇiçek, E.
dc.contributor.authorCenik, A. G.
dc.contributor.authorSıngırık, E.
dc.contributor.authorKılıç, M.
dc.contributor.authorÖzcan, A. S.
dc.date.accessioned2020-03-26T16:24:14Z
dc.date.available2020-03-26T16:24:14Z
dc.date.issued1991
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe contribution of intra- and extracellular Ca++ during KCl- and 5-hydroxytryptamine-induced contractions was investigated in human isolated umbilical arteries obtained from cords of normal full-term deliveries. In normal solution, nifedipine caused dose-dependent relaxations of the arteries contracted by high K+ (80 mM) and 5-hydroxytryptamine. The IC50 value of nifedipine on KCl-induced contractions was about 9 times lower than that on 5-hydroxytryptamine-induced contractions. In Ca++-free medium, KCl failed to induce contractions of the artery. However, 5-hydroxytryptamine caused contractions amounting to 52 % of the maximum response obtained by re-addition of Ca++, and this response was abolished by 10(-6) M of nifedipine. In the presence of either KCl or 5-hydroxytryptamine, subsequent addition of Ca++ caused reproducible contractions which were also inhibited by nifedipine. These results indicate that the KCl-induced contraction of human isolated umbilical artery is mainly dependent on extracellular Ca++, whereas that induced by 5-hydroxytryptamine involves both intra- and extracellular Ca++. It is also suggested that nifedipine does not only inhibit the influx of extracellular Ca++ during the contraction by 5-hydroxytryptamine but that it may also have intracellular effects.en_US
dc.identifier.citationDoğan, N., Çiçek, E., Cenik, A. G., Kılıç, M., Özcan, A. S., (1991). 5-Hydroxytryptamine-Induced Contraction of Human Isolated Umbilical Artery and Its Dependence on Cellular and Extracellular Ca++. Archives Internationales De Pharmacodynamie Et De Therapie, 312, 79-85.
dc.identifier.endpage85en_US
dc.identifier.issn0003-9780en_US
dc.identifier.pmid1772342en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16105
dc.identifier.volume312en_US
dc.identifier.wosWOS:A1991GT04900006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherARCH INT PHARMACODYNAMIEen_US
dc.relation.ispartofArchives Internationales De Pharmacodynamie Et De Therapieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.title5-Hydroxytryptamine-Induced Contraction of Human Isolated Umbilical Artery and Its Dependence on Cellular and Extracellular Ca++en_US
dc.typeArticleen_US

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