Effects of iloprost and piracetam in spinal cord ischemia-reperfusion injury in the rabbit

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dc.contributor.authorKalkan, E.
dc.contributor.authorKeskin, F.
dc.contributor.authorKaya, B.
dc.contributor.authorEsen, H.
dc.contributor.authorTosun, M.
dc.contributor.authorKalkan, S. S.
dc.contributor.authorErdi, F.
dc.date.accessioned2020-03-26T18:14:23Z
dc.date.available2020-03-26T18:14:23Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractStudy design: Experimental Study. Objectives: The aim of this study was to investigate the neuroprotective effects of iloprost and piracetam on spinal cord ischemia/reperfusion (I/R) injury in the rabbit. Settings: The Experimental Research Center of Selcuk University, Konya, Turkey. Methods: A total of 24 rabbits were divided into four groups of six rabbits each, as follows: group 1 (n = 6) sham, laparotomy only; group 2 (n = 6) I/R; group 3 (n = 6) I/R + iloprost; and group 4 (n = 6) I/R + piracetam. I/R was established in groups 2, 3 and 4. Subsequently, they were followed up neurologically for 24 h until the rabbits were killed; biochemical and histopathological examinations of samples from the spinal cord were carried out. Results: Neurological examination results were significantly better in the iloprost and piracetam groups compared with the I/R group (P<0.05). Neuroprotection was achieved with iloprost and piracetam by suppressing malondialdehyde (P<0.05), increasing glutathione peroxidase activity (P<0.05) and decreasing the xanthine oxidase level. In histopathological assessment, iloprost and piracetam groups were statistically different from the I/R group in terms of the number of apoptotic neurons in gray matter and white matter, as well as in terms of degenerated neurons and glial cells (P<0.05). No statistical difference was determined between the four groups in the number of degenerated glial cells (P>0.05). Conclusion: This study has shown that iloprost and piracetam have neuroprotective effects in I/R injury both neurologically and histopathologically because of inhibition of lipid peroxidation. Spinal Cord (2011) 49, 81-86; doi: 10.1038/sc.2010.76; published online 29 June 2010en_US
dc.identifier.doi10.1038/sc.2010.76en_US
dc.identifier.endpage86en_US
dc.identifier.issn1362-4393en_US
dc.identifier.issue1en_US
dc.identifier.pmid20585328en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://dx.doi.org/10.1038/sc.2010.76
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26410
dc.identifier.volume49en_US
dc.identifier.wosWOS:000285996800014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.relation.ispartofSPINAL CORDen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIloprosten_US
dc.subjectischemia-reperfusionen_US
dc.subjectoxidative injuryen_US
dc.subjectpiracetamen_US
dc.subjectspinal corden_US
dc.titleEffects of iloprost and piracetam in spinal cord ischemia-reperfusion injury in the rabbiten_US
dc.typeArticleen_US

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