Increased myocardial vulnerability and autonomic nervous system imbalance in obstructive sleep apnea syndrome

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dc.contributor.authorAytemir, Kudret
dc.contributor.authorDeniz, Ali
dc.contributor.authorYavuz, Bunyamin
dc.contributor.authorDemir, Ahmet Ugur
dc.contributor.authorSahiner, Levent
dc.contributor.authorCiftci, Orcun
dc.contributor.authorTokgozoglu, Lale
dc.date.accessioned2020-03-26T17:17:32Z
dc.date.available2020-03-26T17:17:32Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Obstructive steep apnea syndrome (OSAS) is characterized by the repeated episodes of upper airway obstruction during steep, leading to significant hypoxia. Noninvasive evaluation of autonomic nervous system (ANS) and myocardial vulnerability may help determination of OSAS patients who are under high risk of malignant cardiac arrhythmias. The aim of this study was to show the effects of OSAS on predictors of arrhythmias by the evaluation of heart rate turbulence (HRT), heart rate variability (HRV) and QT dynamicity reflecting the ANS balance and myocardial vulnerability. Methods: After polysomnographic study, 80 patients with OSAS and 55 age matched OSAS (-) subjects were included in the study. Twenty-four-hour Hotter monitoring was performed in all subjects. HRT, HRV and QT dynamicity parameters were calculated. Results: Turbulence slope was significantly decreased in OSAS patients whereas turbulence onset was increased (P < 0.001). QT/RR slopes were significantly increased for QT end and QTapex (P < 0.001). In HRV analysis, autonomic balance changed in favor of sympathetic system at night in OSAS patients. Furthermore, HRT and QT dynamicity parameters are found to be correlated with Apnea-Hypopnea Index (AHI). Conclusion: OSAS is associated with a significant worsening in HRV, HRT, and QT dynamicity parameters. Our results may indicate that HRV and QT dynamicity parameters can be useful noninvasive methods that may detect autonomic nervous system activity and ventricular vulnerability in OSAS. (c) 2006 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.rmed.2006.10.016en_US
dc.identifier.endpage1282en_US
dc.identifier.issn0954-6111en_US
dc.identifier.issn1532-3064en_US
dc.identifier.issue6en_US
dc.identifier.pmid17137777en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1277en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.rmed.2006.10.016
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21429
dc.identifier.volume101en_US
dc.identifier.wosWOS:000247313000030en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO LTDen_US
dc.relation.ispartofRESPIRATORY MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectOSASen_US
dc.subjectQT dynamicityen_US
dc.subjectHRVen_US
dc.subjectarrhythmiaen_US
dc.titleIncreased myocardial vulnerability and autonomic nervous system imbalance in obstructive sleep apnea syndromeen_US
dc.typeArticleen_US

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