Effects of gamma-hydroxybutyrate on cerebrospinal fluid lactate and glucose levels after spinal cord trauma

Basit Öğe Kaydı
dc.contributor.authorGuney, O
dc.contributor.authorCelik, JB
dc.contributor.authorArazi, M
dc.contributor.authorUstun, ME
dc.date.accessioned2020-03-26T16:48:26Z
dc.date.available2020-03-26T16:48:26Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study aims to evaluate the effects of gamma-hydroxybutyrate (GHB) after spinal cord trauma (SCT). Twenty rabbits were divided equally into four groups: group I was the sham-operated group, group 11 suffered from SCT but received no treatment, group III was given a dose of 400 mg/kg of GHB intravenously before SCT and group IV received the same dose after SCT. Cerebrospinal fluid (CSF) samples were obtained 30 min before SCT (T-0), at 60 (T-1) and 120 min (T-2) after SCT. There was a threefold increase in lactate levels from baseline value at T-2 in group 11, while statistically significant elevation of the lactate levels were not observed in groups III and IV. Glucose levels at T, and T2 were significantly lower in groups III and IV compared with the control group. The findings of this study demonstrate that GHB can control the increase of CSF lactate and glucose levels following SCT and that this metabolic effect may be associated with neuroprotective physiological changes. (C) 2004 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jocn.2003.10.019en_US
dc.identifier.endpage520en_US
dc.identifier.issn0967-5868en_US
dc.identifier.issn1532-2653en_US
dc.identifier.issue5en_US
dc.identifier.pmid15177397en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage517en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jocn.2003.10.019
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19035
dc.identifier.volume11en_US
dc.identifier.wosWOS:000222378700016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofJOURNAL OF CLINICAL NEUROSCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectgamma-hydroxybutyrateen_US
dc.subjectspinal cord traumaen_US
dc.subjectcerebrospinal fluiden_US
dc.titleEffects of gamma-hydroxybutyrate on cerebrospinal fluid lactate and glucose levels after spinal cord traumaen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
PIIS0967586804000700.pdf
Boyut:
120.23 KB
Biçim:
Adobe Portable Document Format
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu