Effect of testosterone supplementation on leptin release in rats after castration and/or unilateral surrenalectomy

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dc.contributor.authorKul, Aylin
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.contributor.authorMogulkoc, Rasim
dc.date.accessioned2020-03-26T18:25:06Z
dc.date.available2020-03-26T18:25:06Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction: The objective of this study was to examine the effect of testosterone supplementation on leptin release in rats which underwent castration and unilateral surrenalectomy. Material and methods: The study was conducted on 80 adult male Wistar albino rats. Animals were divided into eight groups, with ten animals in each group. Group 1 was the Control group, Group 2 the Testosterone group, Group 3 the Castration group, Group 4 the Surrenalectomy group, Group 5 the Castration and Surrenalectomy group, Group 6 the Castration and Testosterone group, Group 7 the Surrenalectomy and Testosterone group, and Group 8 the Castration, Surrenalectomy and Testosterone group. The animals in Groups 2, 6, 7 and 8 were administered 5 mg/kg/day intramuscular testosterone propionate for four weeks. Blood samples were collected for analyses of leptin, LH, FSH and free and total testosterone levels in plasma. Results: Groups 3 and 5 had the highest leptin and LH levels of all the groups (p<0.01). Leptin and LH levels in Groups 1 and 4 were higher than those in Groups 2, 6, 7 and 8 (p<0.01). A comparison of groups with regard to plasma FSH levels showed that the concerned parameter was significantly higher in Groups 3 and 5 than in the other groups (p<0.01). FSH levels in Groups 1 and 4 were lower than those in all other group (p<0.01). The highest testosterone levels were obtained in Groups 2, 6, 7 and 8 (p<0.01). Testosterone levels in Groups 1 and 4 were higher than those in Groups 3 and 5 (p<0.01). Conclusions: This study demonstrates that unilateral surrenalectomy in rats does not have a significant effect on leptin release, while plasma LH levels, rather than testosterone, may be more effective on plasma leptin. (Pol J Endocrinol 2012; 63 (2): 119-124)en_US
dc.identifier.endpage124en_US
dc.identifier.issn0423-104Xen_US
dc.identifier.issue2en_US
dc.identifier.pmid22538751en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage119en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27956
dc.identifier.volume63en_US
dc.identifier.wosWOS:000305768800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVIA MEDICAen_US
dc.relation.ispartofENDOKRYNOLOGIA POLSKAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcastrationen_US
dc.subjectsurrenalectomyen_US
dc.subjecttestosterone supplementationen_US
dc.subjectleptinen_US
dc.titleEffect of testosterone supplementation on leptin release in rats after castration and/or unilateral surrenalectomyen_US
dc.typeArticleen_US

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