Biological correlates of major depression and generalized anxiety disorder in women with polycystic ovary syndrome

Küçük Resim Yok

Tarih

2013

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

PERGAMON-ELSEVIER SCIENCE LTD

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Objective: We aimed to compare the levels of serum androgens in women with polycystic ovary syndrome (PCOS) who had a diagnosis of only major depressive disorder (MDD), only generalized anxiety disorder (GAD) or who had no psychiatric disorder, as determined by a structured clinical interview. Another objective of the study was to examine whether an association exists between these psychiatric diagnoses and insulin resistance or body mass index via a comparison among the study groups in terms of these parameters. Method: This study was performed between March 2011 and February 2012. A total of 73 patients were included in the study. The study sample consisted of three groups: PCOS patients with only major depressive disorder (n = 23), PCOS patients with only generalized anxiety disorder (n = 20), and PCOS patients without any diagnosed psychiatric disorders (not diagnosed - ND group, n = 30). Results: Significant difference was found among the three groups with regard to the serum levels of 17-OHP and DHEAS. When multiple comparisons were performed among the groups, 17-OHP levels were significantly higher in the MDD group than in the ND group. DHEAS levels were significantly higher in the MDD group and the GAD group than in the ND group. Conclusion: The present study suggests that MDD and GAD appear to be associated with higher DHEAS levels. (C) 2013 Elsevier Inc. All rights reserved.

Açıklama

Anahtar Kelimeler

Depression, Generalized anxiety disorder, Hyperandrogenism, Polycystic ovary syndrome

Kaynak

JOURNAL OF PSYCHOSOMATIC RESEARCH

WoS Q Değeri

Q2

Scopus Q Değeri

Q1

Cilt

74

Sayı

3

Künye