Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass: effects on TNF-alpha, IL-6, IL-8, IL-10

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dc.contributor.authorCelik, JB
dc.contributor.authorGormus, N
dc.contributor.authorOkesli, S
dc.contributor.authorGormus, ZI
dc.contributor.authorSolak, H
dc.date.accessioned2020-03-26T16:55:21Z
dc.date.available2020-03-26T16:55:21Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: This study examined the correlation between tumour necrosis factor-alfa (TNF-alpha), interleukin (IL)-6 and IL-8, IL-10 and methylprednisolone pretreatment. Methods: This is a prospective, randomized and double-blinded study. Sixty patients undergoing coronary artery bypass grafting (CABG) were randomized to receive either intravenous methylprednisolone (n = 30, Group M) or intravenous placebo (n = 30, Group S). The patients received intravenously either 30 mg/kg methylprednisolone ( Group M) or placebo (Group S) 10 min before and after cardiopulmonary bypass (CPB). In an intensive care unit (ICU), four additional doses were given at 6-hourly intervals. Blood samples for the measurements of TNF-alpha, IL-6, IL-8 and IL-10 were obtained before induction of anaesthesia (T0 = control value), after induction (T1), before starting CPB (T2), after aortic declamping (T3), at the end of CPB (T4) and 6 hours (T5), 12 hours (T6) and 24 hours (T7) after skin closure. Creatine kinase (CK) and creatine kinase isoenzyme MB (CK-MB) were evaluated at the following intervals: T0, T5, T6 and T7. Results: When compared with the control value, TNF-alpha, IL-6 and IL-8 significantly increased in Group S and Group M (p < 0.05), but these values were significantly greater in Group S than in Group M (p < 0.05). In comparison with the control value, IL-10 increased in both groups (p < 0.05), but was significantly greater in Group M than in Group S (p < 0.05). CK and CK-MB were increased in both groups in postoperative values compared to control values. In Group S, CK and CK-MB levels were significantly lower than in Group M (p < 0.05). Conclusion: In this study, we have found that pre-operative administration of methylprednisolone has decreased TNF-alpha, IL-6 and IL-8 release, and increased the perfusing IL-10 levels after CPB. Thus, methylprednisolone may decrease the inflammatory response during the CPB procedure.en_US
dc.identifier.doi10.1191/0267659104pf733oaen_US
dc.identifier.endpage191en_US
dc.identifier.issn0267-6591en_US
dc.identifier.issn1477-111Xen_US
dc.identifier.issue3en_US
dc.identifier.pmid15298427en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage185en_US
dc.identifier.urihttps://dx.doi.org/10.1191/0267659104pf733oa
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19123
dc.identifier.volume19en_US
dc.identifier.wosWOS:000222788500008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofPERFUSION-UKen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleMethylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass: effects on TNF-alpha, IL-6, IL-8, IL-10en_US
dc.typeArticleen_US

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