Serum galectin-3 level predicts early recurrence following successful direct-current cardioversion in persistent atrial fibrillation patients

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dc.contributor.authorGurses, Kadri Murat
dc.contributor.authorYalçın, Muhammed Ulvi
dc.contributor.authorKoçyiğit, Duygu
dc.contributor.authorCanpınar, Hande
dc.contributor.authorAteş, Ahmet Hakan
dc.contributor.authorCanpolat, Uğur
dc.contributor.authorYorgun, Hikmet
dc.contributor.authorGüç, Dicle
dc.contributor.authorAytemir, Kudret
dc.date.accessioned2020-03-26T20:19:17Z
dc.date.available2020-03-26T20:19:17Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Atrial structural remodeling has been suggested to contribute to atrial fibrillation (AF) recurrence following direct-current cardioversion (DCCV). The role of several inflammatory and extracellular matrix turnover markers in AF recurrence following DCCV has been investigated. However, data on the impact of galectin-3, which is known to play a role in various fibrotic conditions, including cardiac fibrosis are lacking. The aim of this study was to demonstrate the predictive role of serum galectin-3 levels in AF recurrence following successful DCCV. Methods: A total of 90 persistent AF patients who were scheduled for DCCV were prospectively enrolled. Serum samples were assayed to determine pre-DCCV galectin-3 levels using the enzyme-linked immunosorbent assay method. Patients were followed up for 3 months for AF recurrence. Results: Of 90 persistent AF patients (mean age: 55.33 +/- 7.94 years; 53.33% male) who underwent successful DCCV, 28 (31.11%) experienced early AF recurrence within 3 months. Patients with AF recurrence had a greater left atrial volume index (LAVI) (33.35 +/- 2.45 mL/m(2) vs. 29.21 +/- 3.08 mL/m(2); p<0.001) and serum galectin-3 levels were higher (0.88 ng/mL [min-max: 0.52-1.32] vs. 0.60 ng/mL [min-max: 0.38-0.91]; p<0.001). In multivariate analysis, the number of DCCV attempts (hazard ratio [HR]: 1.879, 95% confidence interval [CI]: 1.052-3.355; p=0.033), LAVI (HR: 1.180, 95% CI: 1.028-1.354; p=0.018), and serum galectin-3 level (HR: 11.933, 95% CI: 1.220-116.701; p=0.033) were found to be independently associated with early AF recurrence following successful DCCV. Conclusion: Circulating levels of galectin-3 may have an association with early AF recurrence following DCCV.en_US
dc.description.sponsorshipHacettepe University Scientific Research Projects Coordination UnitHacettepe University [1993]en_US
dc.description.sponsorshipThis project was funded by Hacettepe University Scientific Research Projects Coordination Unit (project number: 1993).en_US
dc.identifier.citationGurses, K. M., Yalçın, M. U., Koçyiğit, D., Canpınar, H., Ateş, A. H., Canpolat, U., Yorgun, H., Güç, D., Aytemir, K. (2019). Serum Galectin-3 Level Predicts Early Recurrence Following Successful Direct-Current Cardioversion İn Persistent Atrial Fibrillation Patients. Archıves Of The Turkısh Socıety Of Cardıology, 47,(7), 564-571.
dc.identifier.doi10.5543/tkda.2019.58399en_US
dc.identifier.endpage571en_US
dc.identifier.issn1016-5169en_US
dc.identifier.issue7en_US
dc.identifier.pmid31582678en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage564en_US
dc.identifier.urihttps://dx.doi.org/10.5543/tkda.2019.58399
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38195
dc.identifier.volume47en_US
dc.identifier.wosWOS:000488637800004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYalçın, Muhammed Ulvi
dc.language.isoenen_US
dc.publisherTURKISH SOC CARDIOLOGYen_US
dc.relation.ispartofTURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAtrial fibrillationen_US
dc.subjectelectrical cardioversionen_US
dc.subjectgalectin-3en_US
dc.subjectremodelingen_US
dc.titleSerum galectin-3 level predicts early recurrence following successful direct-current cardioversion in persistent atrial fibrillation patientsen_US
dc.typeArticleen_US

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