Effects of endothelin and nitric oxide on cardiac muscle functions in experimental septic shock model

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dc.contributor.authorOzer, E. K.
dc.contributor.authorIskit, A. B.
dc.date.accessioned2020-03-26T19:23:49Z
dc.date.available2020-03-26T19:23:49Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe aimed to investigate the possible roles of nitric oxide (NO) and endothelin on the changes of cardiac muscle function in both hyper- and hypodynamic septic shock periods. Cecal ligation and puncture was performed in 50 Wistar albino rats to induce septic shock. Changes in atrium and right ventricle papillary muscle contractions, atrium beat rate, adrenergic and cholinergic responses in these tissues were evaluated in vitro. Atrium beat rate increased in hypodynamic period (p < 0.001) that was reversed by bosentan (p < 0.001) and N-G-nitro-l-arginine methylester (l-NAME; p < 0.05). Atrium contractions decreased in both hyper- and hypodynamic periods (p < 0.001) that were partially ameliorated by bosentan in both periods (p < 0.01) and only in hypodynamic period by l-NAME (p < 0.001). l-NAME increased papillary muscle contractions in both periods (p < 0.01), but bosentan increased it only in hyperdynamic period (p < 0.01). Bosentan and l-NAME increased potency of isoproterenol on atrium beat rate in both periods and increased carbachol potency on atrium beat rate and atrium contraction amplitude only in hypodynamic period. Bosentan increased atrium contraction response to isoproterenol in hypodynamic period (p < 0.05). Papillary muscle contraction response to isoproterenol increased in hypodynamic period (p < 0.05). l-NAME increased papillary muscle contraction response to carbachol in both periods (p < 0.01, p < 0.05, respectively). These results show that NO and endothelin may play a role in positive inotropic and negative chronotropic effects for atrium in septic shock. Bosentan and l-NAME may change potency and efficacy of isoproterenol and carbachol via upregulation of adrenergic and cholinergic receptors and/or through post receptor factors.en_US
dc.identifier.doi10.1177/0960327115583363en_US
dc.identifier.endpage275en_US
dc.identifier.issn0960-3271en_US
dc.identifier.issn1477-0903en_US
dc.identifier.issue3en_US
dc.identifier.pmid25911090en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://dx.doi.org/10.1177/0960327115583363
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33504
dc.identifier.volume35en_US
dc.identifier.wosWOS:000369657300007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofHUMAN & EXPERIMENTAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSepsisen_US
dc.subjectnitric oxideen_US
dc.subjectendothelinen_US
dc.subjectcardiac muscleen_US
dc.titleEffects of endothelin and nitric oxide on cardiac muscle functions in experimental septic shock modelen_US
dc.typeArticleen_US

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