Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.

Basit Öğe Kaydı
dc.contributor.authorUysal, Şengül
dc.contributor.authorUğurlu, Aslı
dc.contributor.authorZengin, Gökhan
dc.contributor.authorBaloğlu, Mehmet Cengiz
dc.contributor.authorAltunoğlu, Yasemin Çelik
dc.contributor.authorMollica, Adriano
dc.contributor.authorCustodio, Luisa
dc.date.accessioned2020-03-26T19:54:51Z
dc.date.available2020-03-26T19:54:51Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBidens tripartita L. is a traditional phyto-remedy used in several countries, yet there is still a paucity of data on its biological potential. We aimed to provide new insights on the pharmacological potential of extracts prepared from B. tripartita via highlighting its antioxidant, key enzymes inhibitory potency, and DNA protecting effects. Phytochemical profile was established using High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD) and bioactive compound(s) docked against target enzymes using in silica methods. Cytotoxicity against three cancer cell lines was assessed using the methylthiazolyldiphenyl-tetrazolium bromide (MTT) cell viability test. The main compounds were luteolin-7-glucoside (cynaroside), chlorogenic acid, and epicatechin in the extracts. The methanol extract exhibited the highest radical scavenging activity. Ethyl acetate extract showed strongest a-amylase inhibitory activity, while the best a-glucosidase inhibitory effect recorded for the methanol extract. Molecular docking showed that cynaroside strongly interact to a-glucosidase cavity by establishing six hydrogen bonds. B. tripartita extracts were found to protect supercoiled form of pUC19 plasmid (>70%) and also showed anti-proliferative properties. Results amassed in the present study add on to a growing body of literature on the multi-pharmacological potency of B. tripartita which can be applied to bio-products development geared towards management of common diseases.en_US
dc.identifier.doi10.1016/j.fct.2017.11.058en_US
dc.identifier.endpage536en_US
dc.identifier.issn0278-6915en_US
dc.identifier.issn1873-6351en_US
dc.identifier.pmid29217268en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage525en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.fct.2017.11.058
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36809
dc.identifier.volume111en_US
dc.identifier.wosWOS:000423248100047en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofFOOD AND CHEMICAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnti-proliferativeen_US
dc.subjectAntioxidanten_US
dc.subjectalpha-glucosidaseen_US
dc.subjectDNA protectionen_US
dc.subjectAnti-canceren_US
dc.subjectCholinesterasesen_US
dc.titleNovel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu