Role of curcumin in mesenteric ischemia - reperfusion injury in rats

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dc.contributor.authorAtalık, Kısmet Esra Nurullahoğlu
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorBelviranlı, Muaz
dc.contributor.authorGökbel, Hakkı
dc.contributor.authorÖz, Mehmet
dc.contributor.authorEsen, H.
dc.date.accessioned2020-03-26T18:31:14Z
dc.date.available2020-03-26T18:31:14Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Curcumin is an antioxidant molecule that has been shown to attenuate ischemia/reperfusion (I/R) injury in several organ systems. In the present study, we aimed to evaluate the possible effects of curcumin on contractile response to agonists and histopathological alterations in rat esophagus subjected to mesenteric I/R. Materials and methods: Adult male Wistar albino rats were randomly allocated to 4 groups, namely group I: sham-operated animals (n=10); group II: animals subdued to I/R injury only (n=10) and laparotomy; 45 minutes of superior mesenteric artery ligation were followed by 2 hours of reperfusion, group III: curcumin/sham (n=10); 20 days before I/R, curcumin (200 mg/kg/) was administered by gastric gavage, and group IV: curcumin-I/R (n=10). Mesenteric ischemia/reperfusion model was generated by clamping the superior mesenteric artery for 45 min followed by reperfusion for 2 h. Oral administration of curcumin by gavage at a dose of 200 mg/kg/day lasted 20 days just before inducing the mesenteric ischemia. At the end of reperfusion period, all animals were sacrificed and esophagus samples were collected to assess the contractile response to agonists and histopathological alterations. Results: Ischemia/reperfusion significantly decreased the contractile responses to carbachol and KCl and this decrease was attenuated by curcumin. Pretreatment with curcumin caused a remarkable decrease in histopathological parameters such as edema, congestion and inflammatory cells. Conclusions: The results of the present study demonstrate for the first time that curcumin can attenuate the esophageal injury associated with I/R (Tab. 4, Fig. 3, Ref. 32). Full Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2012_103en_US
dc.identifier.endpage470en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issue8en_US
dc.identifier.pmid22897369en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage465en_US
dc.identifier.urihttps://dx.doi.org/10.4149/BLL_2012_103
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28378
dc.identifier.volume113en_US
dc.identifier.wosWOS:000307990400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcontractile functionen_US
dc.subjectcurcuminen_US
dc.subjectesophagusen_US
dc.subjectmesenteric ischemiaen_US
dc.titleRole of curcumin in mesenteric ischemia - reperfusion injury in ratsen_US
dc.typeArticleen_US

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