Protective effect of L-carnitine in a rat model of retinopathy of prematurity

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dc.contributor.authorKeles, Sadullah
dc.contributor.authorCaner, Ibrahim
dc.contributor.authorAtes, Orhan
dc.contributor.authorCakici, Ozgur
dc.contributor.authorSaruhan, Fatih
dc.contributor.authorMumcu, Ugur Yilmaz
dc.contributor.authorUnal, Deniz
dc.date.accessioned2020-03-26T18:58:26Z
dc.date.available2020-03-26T18:58:26Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: To investigate the effects of L-carnitine (LC) on rats with oxygen-induced retinopathy. Materials and methods: The study was conducted on 40 Sprague Dawley rat pups. The rat pups were randomly divided into 4 groups: group 1 (n = 10), the healthy control group with intraperitoneal 0.1 mL/day physiological saline injection; group 2 (n = 10), exposed to hyperoxygen, did not receive LC but received 0.1 mL/day physiological saline intraperitoneally; group 3 (n = 10), exposed to hyperoxygen and received 100 mg/kg/day LC intraperitoneally; group 4 (n = 10), exposed to hyperoxygen and received 200 mg/kg/day LC intraperitoneally. After postnatal day 20, the rat pups were killed and an histological examination was performed on the eyes, in addition to the detection of plasma malondialdehyde (MDA) levels. Results: The retinal and choroidal histopathological changes due to hyperoxygen were less in group 3 and minimal in group 4 compared with group 2. Compared with the healthy control group, the increase in the MDA levels in group 2 was significant (P < 0.05). Compared with group 2 there was a significant (P < 0.05) decrease in the MDA levels in groups 3 and 4. Conclusion: LC has beneficial effects on oxygen-induced retinopathy in rats in terms of histopathological changes and MDA levels.en_US
dc.identifier.doi10.3906/sag-1301-9en_US
dc.identifier.endpage475en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue3en_US
dc.identifier.pmid25558651en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage471en_US
dc.identifier.urihttps://dx.doi.org/10.3906/sag-1301-9
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31095
dc.identifier.volume44en_US
dc.identifier.wosWOS:000334063700020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEYen_US
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectL-carnitineen_US
dc.subjectmalondialdehydeen_US
dc.subjectoxygen toxicityen_US
dc.subjectretinopathy of prematurityen_US
dc.titleProtective effect of L-carnitine in a rat model of retinopathy of prematurityen_US
dc.typeArticleen_US

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