The Relationship between Metabolic Parameters, Cardiac Parameters and MIC-1/GDF15 in Obese Children

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dc.contributor.authorYuca, S. A.
dc.contributor.authorCimbek, E. A.
dc.contributor.authorSen, Y.
dc.contributor.authorGuevenc, O.
dc.contributor.authorVatansev, H.
dc.contributor.authorBugrul, F.
dc.contributor.authorGun, F.
dc.date.accessioned2020-03-26T19:43:07Z
dc.date.available2020-03-26T19:43:07Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Childhood obesity which is a predictor of adulthood obesity is associated with type 2 diabetes, metabolic syndrome, dyslipidemia, coronary artery diseases and subclinical inflammation. Growth differentiation factor-15, also known as macrophage inhibitory cytokine-1 (MIC-1/GDF15) is a member of the transforming growth factor-super family and increases during inflammatory states. Adults with obesity have increased serum concentrations of MIC-1/GDF15.MIC-1/GDF15 is associated with cardio metabolic risk in adults. Design: Identification of obese children at higher risk for cardio metabolic complications is important. The relations of MIC-1/GDF15 to parameters of obesity in children have never been studied. Methods: We measured serum MIC-1/GDF15 concentration in obese children by ELSA and evaluated its relationship with anthropometric, biochemical and echocardiographic parameters. Results: No significant difference in serum MIC-1/GDF15 between normal-weight and obese children was observed. MIC-1/GDF15 was positively correlated with CRP, ALT and aortic dimension when normal-weight and obese children were analyzed together. Conclusions: MIC-1/GDF15 may provide a link between childhood obesity and cardio metabolic complications that will occur in time course. Further work would be required to find out if MIC-1/GDF15 has any role in the early inflammatory, cardiac and metabolic changes in childhood obesity.en_US
dc.description.sponsorshipScientific Research Projects of Selcuk UniversitySelcuk University [14401051]en_US
dc.description.sponsorshipThis research was supported by the Scientific Research Projects of Selcuk University with a research grant numbered 14401051.en_US
dc.identifier.doi10.1055/s-0042-114220en_US
dc.identifier.endpage90en_US
dc.identifier.issn0947-7349en_US
dc.identifier.issn1439-3646en_US
dc.identifier.issue2en_US
dc.identifier.pmid27750354en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage86en_US
dc.identifier.urihttps://dx.doi.org/10.1055/s-0042-114220
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35605
dc.identifier.volume125en_US
dc.identifier.wosWOS:000395508000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBHen_US
dc.relation.ispartofEXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectobesityen_US
dc.subjectMIC-1/GDF15en_US
dc.subjectinflammationen_US
dc.subjectcardiovascular risk managementen_US
dc.titleThe Relationship between Metabolic Parameters, Cardiac Parameters and MIC-1/GDF15 in Obese Childrenen_US
dc.typeArticleen_US

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