Association of ring box-1 protein overexpression with clinicopathologic prognostic parameters in prostate carcinoma

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dc.contributor.authorCelik, Zeliha Esin
dc.contributor.authorKaynar, Mehmet
dc.contributor.authorDobur, Fatma
dc.contributor.authorKarabagli, Pinar
dc.contributor.authorGoktas, Serdar
dc.date.accessioned2020-03-26T19:23:10Z
dc.date.available2020-03-26T19:23:10Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: To determine the expression of Ring Box-1 (RBX-1) protein in prostate carcinoma (PCa) and the association between RBX-1 expression and clinicopathologic prognostic parameters. Material and methods: Relevant data such as age, preoperative serum PSA values, and tumor stage were obtained from 51 patients' with PCa record who underwent radical prostatectomy between January 2010 and March 2014. Hematoxylin-eosin stained pathology slides were evaluated by 2 pathologists blinded to patients' data in order to determine Gleason grade groups, tumor stage, tumor volume, capsule invasion, lymphovascular invasion, perineural invasion, and seminal vesicle invasion Immunoreactivity scoring system (IRS) was used to determine RBX-1 expressions. Results: A statistically significant difference was determined in terms of RBX-1 expression between non tumoral prostate tissue, high grade prostatic intraepithelial neoplasia (H-PIN) and carcinoma foci (P = 0.001). RBX-1 expression in the Gleason pattern 4 was higher than the Gleason pattern 3 and H-PIN foci as well as non tumoral prostate tissue. Likewise, in cases with PSA levels of > 10.1 ng/ml, RBX-1 expression was higher than those <= 10 ng/ml. Moreover, RBX-1 expression of stage II cases was higher than stage I (P = 0.019), RBX-1 expression of stage III higher than stage I cases (P = 0.044). However, RBX-1 expression was not related with clinicopathologic parameters including patient age, tumor volume, lymphovascular invasion, perineural invasion, seminal vesicle invasion, or capsule invasion. Conclusions: RBX-1 protein is overexpressed in PCa and associated with clinicopathologic prognostic parameters related with biological potential of the aggressive disease. Further studies of basic and molecular science are needed to reveal clinical and therapeutic implications of RBX-1 in PCa. (C) 2016 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.urolonc.2016.03.008en_US
dc.identifier.issn1078-1439en_US
dc.identifier.issn1873-2496en_US
dc.identifier.issue8en_US
dc.identifier.pmid27085489en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.urolonc.2016.03.008
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33297
dc.identifier.volume34en_US
dc.identifier.wosWOS:000382215300006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofUROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRing box-1en_US
dc.subjectProstate carcinomaen_US
dc.subjectImmunohistochemistryen_US
dc.titleAssociation of ring box-1 protein overexpression with clinicopathologic prognostic parameters in prostate carcinomaen_US
dc.typeArticleen_US

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