Parathyroid autotransplantation in rats having hypoparathyroidism

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dc.contributor.authorErikoglu, Mehmet
dc.contributor.authorColak, Bayram
dc.contributor.authorToy, Hatice
dc.contributor.authorGurbilek, Mehmet
dc.date.accessioned2020-03-26T19:06:35Z
dc.date.available2020-03-26T19:06:35Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractRe-implantation techniques of extracted parathyroid tissue were developed in order to prevent temporary hypocalcemia. During thyroid surgery; inadvertently removed or devascularized parathyroid gland is usually implanted in the sternocleidomastoid muscle. In this experimental study using rats with hypoparathyroidism, our aim was to investigate whether the excised parathyroid tissue could be seeded in the liver and in the peritoneum, instead of the SCM muscle. In our study, four different groups, each consisting of 10 Wistar albino rats were used (Control group, sternocleidomastoid muscle group, liver group, peritoneum group). Parathyroidectomy was performed and the parathyroid tissue was seeded into the sternocloid mastoid muscle, liver and peritoneum. After 14 days, the rats were sacrificed and levels of calcium, magnesium, phosphorus, alkaline phosphatase and parathyroid hormone were measured in rats' blood samples. The autotransplanted parathyroid tissue was then excised and examined. In all groups, parathyroid tissues were analyzed histopathologically according to calcification, necrosis, tissue loss, foreign body reaction, inflammation and fibrosis. Regarding Ca, Mg, PO4, ALP; There were no difference between the groups. When we compared control group with the other groups; a difference was observed in the levels of PTH (P<0.05). In pathological examination; regarding tissue loss; there was a difference between liver and peritoneum groups (P<0.05). In our study, we expected better result in plantings inside liver and peritone compared to SKM. However, there were no difference between the groups.en_US
dc.identifier.endpage16333en_US
dc.identifier.issn1940-5901en_US
dc.identifier.issue9en_US
dc.identifier.pmid26629152en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage16328en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32408
dc.identifier.volume8en_US
dc.identifier.wosWOS:000365273300091en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-CENTURY PUBLISHING CORPen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectParathyroiden_US
dc.subjectautotransplantationen_US
dc.subjecthypocalcemiaen_US
dc.titleParathyroid autotransplantation in rats having hypoparathyroidismen_US
dc.typeArticleen_US

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