Intestinal Involvement in Metachromatic Leukodystrophy

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dc.contributor.authorYavuz, Haluk
dc.contributor.authorYuksekkaya, Hasan Ali
dc.date.accessioned2020-03-26T18:14:58Z
dc.date.available2020-03-26T18:14:58Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractMetachromatic leukodystrophy is a lysosomal storage disease caused by the deficiency of the enzyme arylsulfatase A. If arylsulfatase A is deficient, sulfatide accumulates. Functionally, this accumulation results in progressive neurological deterioration. The reports about the extra nervous system manifestations of metachromatic leukodystrophy are related to the gallbladder involvement such as polyposis. Unexplained vomiting began in a 51/2-year-old girl with late infantile metachromatic leukodystrophy. Endoscopy showed multiple polypoid masses in the pylor of the stomach and duodenum. Severe gastrointestinal bleedings occurred during nasogastric feeding. Intestinal intussusception developed later. To the authors' knowledge, intestinal polypoid masses and obstruction with meta-chromatic leukodystrophy have not previously been reported. The persistent vomiting may be a symptom of intestinal obstruction due to intestinal polypoid masses with metachromatic leukodystrophy. There may be a trend for the development of polypoid masses in intestine as well as in the gallbladder in metachromatic leukodystrophy.en_US
dc.identifier.doi10.1177/0883073810378166en_US
dc.identifier.endpage120en_US
dc.identifier.issn0883-0738en_US
dc.identifier.issue1en_US
dc.identifier.pmid21212458en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage117en_US
dc.identifier.urihttps://dx.doi.org/10.1177/0883073810378166
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26571
dc.identifier.volume26en_US
dc.identifier.wosWOS:000286008600020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS INCen_US
dc.relation.ispartofJOURNAL OF CHILD NEUROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectmetachromatic leukodystrophyen_US
dc.subjectvomitingen_US
dc.subjectpolypoid massesen_US
dc.subjectintestinal obstructionen_US
dc.subjectintussusceptionen_US
dc.titleIntestinal Involvement in Metachromatic Leukodystrophyen_US
dc.typeArticleen_US

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