Cornea in PCOS patients as a possible target of IGF-1 action and insulin resistance

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dc.contributor.authorKebapcilar, Ayse Gul
dc.contributor.authorTatar, Mehmet Gurkan
dc.contributor.authorIpekci, Suleyman Hilmi
dc.contributor.authorGonulalan, Gulsum
dc.contributor.authorKorkmaz, Huseyin
dc.contributor.authorBaldane, Suleyman
dc.contributor.authorCelik, Cetin
dc.date.accessioned2020-03-26T18:49:54Z
dc.date.available2020-03-26T18:49:54Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPrevious studies suggest that serum IGF-1 is higher in women with polycystic ovary syndrome (PCOS). The ophthalmologic effects of IGF-1 excess have not yet been investigated in women with PCOS. The aim of the current study is to compare the corneal thickness of patients with PCOS and those of healthy subjects. Forty three patients with PCOS and 30 age-matched and gender-matched healthy individuals were enrolled in this cross-sectional study. Central corneal thickness (CCT) was measured in patients with PCOS and in healthy individuals with an ultrasound pachymeter. IGF-1 values were also determined in the study group. Women with PCOS had significantly higher levels of IGF-1 and homeostasis model assessment (HOMA-IR) levels than the control group. Right and left CCT measurements were higher in the PCOS group than in the control group. A positive correlation between IGF-1 and right and left CCT was identified in both groups. In multiple linear stepwise regression analyses, IGF-1 independently and positively associated with HOMA-IR in women with PCOS. A correlation between total testosterone and CCT was identified in the whole group. In multiple stepwise regression analyses, total testosterone independently and positively associated with left central corneal thickness in the whole group. These findings indicate that PCOS has target organ effects on the eye. Consequently, it can change central corneal thickness. Higher IGF-1 levels seem to be the main causes of increased corneal thickness. Insulin resistance in PCOS is one of the underlying causes and promotes increase in IGF-1. We suggest a careful and detailed corneal evaluation in PCOS patients to prevent the potential risk of increased CCT, in addition to the already-known complications.en_US
dc.identifier.doi10.1007/s00404-014-3353-yen_US
dc.identifier.endpage1263en_US
dc.identifier.issn0932-0067en_US
dc.identifier.issn1432-0711en_US
dc.identifier.issue6en_US
dc.identifier.pmid25022555en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1255en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00404-014-3353-y
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30707
dc.identifier.volume290en_US
dc.identifier.wosWOS:000344771700031en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofARCHIVES OF GYNECOLOGY AND OBSTETRICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPolycystic ovary syndromeen_US
dc.subjectCentral corneal thicknessen_US
dc.subjectInsulin-like growth factor-1en_US
dc.subjectHOMA-IRen_US
dc.titleCornea in PCOS patients as a possible target of IGF-1 action and insulin resistanceen_US
dc.typeArticleen_US

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