Correlation with Neuropsychological Tests and Movement Related Cortical Potentials in Assesing Mild Cognitive Impairment and Middle Stage Alzheimer's Disease
Küçük Resim Yok
Tarih
2013
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
GALENOS YAYINCILIK
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Alzheimer's disease (AD), the most common cause of dementia, has become an important public health issue. There is no definite cure for AD, however, early diagnosis can slow the course of the disease. Mild cognitive impairment (MCI) is a clinical entity defined as the transition between dementia and normal aging in which memory and other cognitive abilities can be affected. MCI is an active process that can convert to different forms of dementia at a rate of approximately 15% per year. Currently, the use of electrophysiological techniques in diagnosing and clinical monitoring of MCI and AD, and during the clinical course of progression from MCI to AD, is limited as compared with structural and functional imaging techniques. In the current study, we aimed to demonstrate that the movement-related cortical potential (MRCP) test is an electrophysiological test that can be used in the above-mentioned conditions. Methods: In the current study, MRCPs were recorded in 20 patients diagnosed with AD according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) and the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria and, 20 patients diagnosed with MCI according to the Petersen criteria, by using a neuropsychological battery, including the mini-mental state examination, verbal memory processes test, clock-drawing test, geriatric depression scale, Stroop test, functional activities questionnaire, Benton facial recognition test, and the global deterioration scale. Latency and amplitude values of the MRCPs in patients were compared with latency and amplitude values of the MRCPs in 25 normal control cases. Results: Comparison of the AD, MCI and control groups revealed that MRCP wave occurred later in the MCI group than in the control group, and occurred later in the AD group than in the MCI group. Motor potential (MP) amplitude in the AD group was lower as compared with the MCI and control groups. Conclusion: In conclusion, the MRCP test can be used as an electrophysiological test in the diagnosis and monitoring of AD as well as in the monitoring of the clinical course of progression from MCI to AD. (Archives of Neuropsychiatry 2013; 50: 9-14)
Açıklama
Anahtar Kelimeler
Alzheimer's disease, mild cognitive impairment, movement-related cortical potentials
Kaynak
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
50
Sayı
1
