Correlation with Neuropsychological Tests and Movement Related Cortical Potentials in Assesing Mild Cognitive Impairment and Middle Stage Alzheimer's Disease

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dc.contributor.authorMutluer, Muzaffer
dc.contributor.authorGuney, Figen
dc.contributor.authorIlhan, Suleyman
dc.date.accessioned2020-03-26T18:41:23Z
dc.date.available2020-03-26T18:41:23Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Alzheimer's disease (AD), the most common cause of dementia, has become an important public health issue. There is no definite cure for AD, however, early diagnosis can slow the course of the disease. Mild cognitive impairment (MCI) is a clinical entity defined as the transition between dementia and normal aging in which memory and other cognitive abilities can be affected. MCI is an active process that can convert to different forms of dementia at a rate of approximately 15% per year. Currently, the use of electrophysiological techniques in diagnosing and clinical monitoring of MCI and AD, and during the clinical course of progression from MCI to AD, is limited as compared with structural and functional imaging techniques. In the current study, we aimed to demonstrate that the movement-related cortical potential (MRCP) test is an electrophysiological test that can be used in the above-mentioned conditions. Methods: In the current study, MRCPs were recorded in 20 patients diagnosed with AD according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) and the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria and, 20 patients diagnosed with MCI according to the Petersen criteria, by using a neuropsychological battery, including the mini-mental state examination, verbal memory processes test, clock-drawing test, geriatric depression scale, Stroop test, functional activities questionnaire, Benton facial recognition test, and the global deterioration scale. Latency and amplitude values of the MRCPs in patients were compared with latency and amplitude values of the MRCPs in 25 normal control cases. Results: Comparison of the AD, MCI and control groups revealed that MRCP wave occurred later in the MCI group than in the control group, and occurred later in the AD group than in the MCI group. Motor potential (MP) amplitude in the AD group was lower as compared with the MCI and control groups. Conclusion: In conclusion, the MRCP test can be used as an electrophysiological test in the diagnosis and monitoring of AD as well as in the monitoring of the clinical course of progression from MCI to AD. (Archives of Neuropsychiatry 2013; 50: 9-14)en_US
dc.identifier.doi10.4274/npa.y6036en_US
dc.identifier.endpage14en_US
dc.identifier.issn1300-0667en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://dx.doi.org/10.4274/npa.y6036
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29336
dc.identifier.volume50en_US
dc.identifier.wosWOS:000316655800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherGALENOS YAYINCILIKen_US
dc.relation.ispartofNOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectmild cognitive impairmenten_US
dc.subjectmovement-related cortical potentialsen_US
dc.titleCorrelation with Neuropsychological Tests and Movement Related Cortical Potentials in Assesing Mild Cognitive Impairment and Middle Stage Alzheimer's Diseaseen_US
dc.typeArticleen_US

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