Effect of iloprost on adrenal medullary grafts in central nervous system transplantation and apoptosis

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dc.contributor.authorCaglar, Sukru
dc.contributor.authorTorun, Fuat
dc.contributor.authorErdemli, Esra
dc.contributor.authorTorun, Ayse N.
dc.date.accessioned2020-03-26T17:17:17Z
dc.date.available2020-03-26T17:17:17Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To investigate whether iloprost, a stable analog of prostacyclin, is useful for the preservation of neural grafts in transplantation surgery. Methods: This study was conducted at the Microsurgery Laboratory of the Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey in 2003. The animals (rabbits) were divided into 3 groups. In group I, autografts taken from the adrenal medulla were stored in 0.9% sodium chloride (NaCl) solution for 45 minutes before transplantation. In group II, autografts taken from the adrenal medulla were stored in iloprost solution (50 ng/ ml) for 45 minutes before transplantation. Graft transplantation was not performed in the third group. Results: In group 1, the grafts partially preserved their viability. In group II, the large adrenal medullary cells had evident euchromatin nuclei fused with neurons, and there was an increase in vascularization. Conclusions: Three weeks after transplantation surgery, it was determined that iloprost maintained the viability of the graft tissue and probably prevented apoptosis, and facilitated the integration of the graft tissue into the host brain.en_US
dc.identifier.endpage119en_US
dc.identifier.issn1319-6138en_US
dc.identifier.issue2en_US
dc.identifier.pmid21857590en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage114en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21341
dc.identifier.volume12en_US
dc.identifier.wosWOS:000246855400004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRIYADH ARMED FORCES HOSPITALen_US
dc.relation.ispartofNEUROSCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEffect of iloprost on adrenal medullary grafts in central nervous system transplantation and apoptosisen_US
dc.typeArticleen_US

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