Evaluation of the efficacy of methotrexate and cyclosporine therapies on psoriatic nails: a one-blind, randomized study

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dc.contributor.authorGumusel, M.
dc.contributor.authorOzdemir, M.
dc.contributor.authorMevlitoglu, I.
dc.contributor.authorBodur, S.
dc.date.accessioned2020-03-26T18:14:36Z
dc.date.available2020-03-26T18:14:36Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground Treatment of psoriatic nail is difficult. Objective The aim of this study was to evaluate and compare the efficacy and safety of methotrexate and cyclosporine in psoriatic nail. Methods Thirty-seven psoriatic patients with nail involvement were randomized to treatment with methotrexate (initial dose, 15 mg per week) or cyclosporine (initial dose, 5 mg per kg of bodyweight per day) for 24 weeks. The primary outcome was the Nail Psoriasis Severity Index (NAPSI). The Psoriasis Area and Severity Index (PASI), doctor and patient global score were also measured. The scores were determined by a blinded observer. Results Seventeen patients completed the study in each group. The mean percentages of reduction of the NAPSI score after methotrexate and cyclosporine treatments were 43.3% and 37.2%, respectively. No significant differences between the treatment groups was found for in the NAPSI, PASI, physician's and patient's global score at the end of the study period. The methotrexate group showed a significant improvement in nail matrix scores and the cyclosporine group in nail bed score. Conclusion Moderate effectiveness on psoriatic nail was found in the two treatment agents and there were no significant differences in efficacy between the groups. A significant improvement was detected in methotrexate group for the nail matrix findings, and in cyclosporine group for the nail bed findings.en_US
dc.identifier.doi10.1111/j.1468-3083.2010.03927.xen_US
dc.identifier.endpage1084en_US
dc.identifier.issn0926-9959en_US
dc.identifier.issn1468-3083en_US
dc.identifier.issue9en_US
dc.identifier.pmid21118309en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1080en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1468-3083.2010.03927.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26473
dc.identifier.volume25en_US
dc.identifier.wosWOS:000293556400013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcyclosporineen_US
dc.subjectmethotrexateen_US
dc.subjectNAPSIen_US
dc.subjectpsoriatic nailen_US
dc.titleEvaluation of the efficacy of methotrexate and cyclosporine therapies on psoriatic nails: a one-blind, randomized studyen_US
dc.typeArticleen_US

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