Prognostic significance of solid growth in endometrioid endometrial adenocarcinoma

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dc.authorid0000-0002-0466-140X
dc.contributor.authorAkar, Serra.
dc.contributor.authorÇelik, Zeliha Esin.
dc.contributor.authorFındık, Sıddıka.
dc.contributor.authorİlhan, Tolgay Tuyan.
dc.contributor.authorErcan, Fedi.
dc.contributor.authorÇelik, Çetin.
dc.date.accessioned2020-03-26T20:20:26Z
dc.date.available2020-03-26T20:20:26Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground Endometrioid endometrial cancer is the most common histological subtype of endometrial adenocarcinoma. In the FIGO grading scheme, both architectural and nuclear grade are taken into consideration. However, the specific impact of solid growth alone on endometrioid endometrial adenocarcinoma outcome is not well documented. We sought to assess the degree of impact of solid growth on lymphovascular space invasion (LVSI), myometrial invasion, tumor size, FIGO stage, lymph node metastasis (LNM), relapse-free survival (RFS) and disease-specific survival (DSS). Methods Paraffin blocks of 269 patients treated for endometrioid endometrial cancer were retrospectively analyzed with morphometry for solid growth percentages. Results A statistically significant cut-off value of 1% solid growth was found for predicting LNM and advanced stage (III or IV), myometrial invasion and LVSI (p < 0.001) and a cut-off value of 8% was found for predicting adverse survival outcome (p < 0.001). The mean DSS was significantly higher in patients with < 6% solid growth compared to patients with 6-50%, 51-75% and > 75% solid growth (p < 0.001). Although, the mean RFS and DSS were lowest in patients with 51-75% solid growth, this did not reach statistical significance in comparison to 6-50% and > 75% (p > 0.05). Conclusion Although > 75% solid growth was most significantly associated with many of the adverse prognostic factors, this subset did not provide prognostic superiority in predicting adverse survival when compared to subsets within 6-75% solid growth. In conclusion, although no statistically significant difference in survival was found among subdivisions of architectural grades 2 and 3, solid growth, especially >= 8%, appeared to be an independent prognostic factor for survival in patients with early-stage endometrioid endometrial cancer.en_US
dc.identifier.citationAkar, S., Çelik, Z. E., Fındık, S., İlhan, T. T., Ercan, F., Çelik, Ç. (2020). Prognostic Significance of Solid Growth in Endometrioid Endometrial Adenocarcinoma. International Journal of Clinical Oncology, 25(1), 195-202.
dc.identifier.doi10.1007/s10147-019-01529-4en_US
dc.identifier.endpage202en_US
dc.identifier.issn1341-9625en_US
dc.identifier.issn1437-7772en_US
dc.identifier.issue1en_US
dc.identifier.pmid31452018en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage195en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10147-019-01529-4
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38586
dc.identifier.volume25en_US
dc.identifier.wosWOS:000511143000020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAkar, Serra.
dc.institutionauthorÇelik, Zeliha Esin.
dc.institutionauthorİlhan, Tolgay Tuyan.
dc.institutionauthorÇelik, Çetin.
dc.language.isoenen_US
dc.publisherSPRINGER JAPAN KKen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF CLINICAL ONCOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEndometrial canceren_US
dc.subjectSolid growthen_US
dc.subjectArchitectural gradeen_US
dc.subjectPrognosisen_US
dc.subjectSurvivalen_US
dc.titlePrognostic significance of solid growth in endometrioid endometrial adenocarcinomaen_US
dc.typeArticleen_US

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