Diagnostic efficacy of diffusion-weighted MRI for pre-operative assessment of myometrial and cervical invasion and pelvic lymph node metastasis in endometrial carcinoma

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dc.contributor.authorKoplay, Mustafa
dc.contributor.authorDogan, Nasuh Utku
dc.contributor.authorErdogan, Hasan
dc.contributor.authorSivri, Mesut
dc.contributor.authorErol, Cengiz
dc.contributor.authorNayman, Alaaddin
dc.contributor.authorKarabagli, Pinar
dc.date.accessioned2020-03-26T18:50:05Z
dc.date.available2020-03-26T18:50:05Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction: To determine the diagnostic accuracy of diffusion-weighted magnetic resonance imaging (DW-MRI) for the pre-operative assessment of patients with endometrial carcinoma and to assess myometrial and cervical invasion as well as pelvic lymph node metastasis. Methods: Fifty-eight women who underwent surgery for histopathologically confirmed endometrial carcinoma were included in the current study. Prior to surgery, patients were evaluated using pelvic DW-MRI and gadolinium-enhanced T1-weighted imaging (Gd-T1WI). Gd-T1WI was evaluated together with T2-weighted images. DW-MR images were obtained in the axial plane using echo-planar spin-echo pulse sequences with different b factors. Endometrial carcinomas were observed as areas of increased intensity on DW-MRI images, and their intensity was compared with the surrounding hypo-intense myometrium. Pre-operative DW-MRI and Gd-T1WI results were compared with post-operative histopathological findings that served as reference standards. Results: The sensitivity, specificity, positive (PPV) and negative predictive values (NPV), and diagnostic accuracy of DW-MRI for differentiation between superficial myometrial invasion and deep myometrial invasion were 85%, 89%, 81%, 92% and 88%, respectively. The sensitivity, specificity and diagnostic accuracy rates were 82%, 91% and 89.6% for cervical invasion and 100%, 96% and 96.5% for pelvic lymph node metastasis, respectively. The sensitivity, specificity, PPV and NPV, and diagnostic accuracy of Gd-T1WI for differentiation between superficial myometrial invasion and deep myometrial invasion were 85%, 81.5%, 71%, 91% and 83%, respectively. The sensitivity, specificity and diagnostic accuracy were 73%, 89% and 86% for cervical invasion, respectively. Conclusions: These findings suggest that DW-MRI may be a good diagnostic tool with high sensitivity and specificity for assessing myometrial invasion and detecting tumour extension. We suggest that DW-MRI should be considered as a routine part of the pre-operative pelvic MRI in all patients with endometrial carcinoma.en_US
dc.identifier.doi10.1111/1754-9485.12209en_US
dc.identifier.endpage546en_US
dc.identifier.issn1754-9477en_US
dc.identifier.issn1754-9485en_US
dc.identifier.issue5en_US
dc.identifier.pmid25046775en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage538en_US
dc.identifier.urihttps://dx.doi.org/10.1111/1754-9485.12209
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30743
dc.identifier.volume58en_US
dc.identifier.wosWOS:000345630000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofJOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectdiffusion-weighted imagingen_US
dc.subjectendometrial carcinomaen_US
dc.subjectMRIen_US
dc.subjectstagingen_US
dc.titleDiagnostic efficacy of diffusion-weighted MRI for pre-operative assessment of myometrial and cervical invasion and pelvic lymph node metastasis in endometrial carcinomaen_US
dc.typeArticleen_US

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