Triterpene acid and phenolics from ancient apples of friuli venezia giulia as nutraceutical ingredients: lC-MS study and in vitro activities

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dc.authorid0000-0002-7865-1634
dc.authorid0000-0001-6548-7823
dc.authorid0000-0003-1375-4744
dc.authorid0000-0002-1936-5216
dc.authorid0000-0001-8264-6953
dc.contributor.authorSut, Stefania
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMaggi, Filippo
dc.contributor.authorMalagoli, Mario
dc.contributor.authorDall'Acqua, Stefano
dc.date.accessioned2020-03-26T20:19:40Z
dc.date.available2020-03-26T20:19:40Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractTriterpene acid and phenolic constituents from nine ancient varieties of apple (Malus domestica) fruits cultivated in Fanna, Friuli Venezia Giulia region, northeast Italy, were analyzed and compared with four commercial apples (Golden Delicious', Red Delicious', Granny Smith' and Royal Gala'). Total phenolic and flavonoid contents were measured by spectrophotometric assays. The quali-quantitative fingerprint of secondary metabolites including triterpene acid was obtained by LC-DAD-(ESI)-MS and LC-(APCI)-MS, respectively. Based on the two LC-MS datasets, multivariate analysis was used to compare the composition of ancient fruit varieties with those of four commercial apples. Significant differences related mainly to the pattern of triterpene acids were found. Pomolic, euscaphyc, maslinic and ursolic acids are the most abundant triterpene in ancient varieties pulps and peels, while ursolic and oleanolic acids were prevalent in the commercial fruits. Also, the content of the phenolic compounds phloretin-2-O-xyloglucoside and quercetin-3-O-arabinoside was greater in ancient apple varieties. The antioxidant (radical scavenging, reducing power, metal chelating and phosphomolybdenum assays) and enzyme inhibitory effects (against cholinesterase, tyrosinase, amylase and glucosidase) of the samples were investigated in vitro. Antioxidant assays showed that the peels were more active than pulps. However, all the samples exhibited similar enzyme inhibitory effects. Ancient Friuli Venezia Giulia apple cultivars can be a source of chlorogenic acid and various triterpene acids, which are known for their potential anti-inflammatory activity and beneficial effects on lipid and glucose metabolism. Our results make these ancient varieties suitable for the development of new nutraceutical ingredients.en_US
dc.identifier.citationSut, S., Zengin, G., Maggi, F., Malagoli, M., Dall’Acqua, S. (2019). Triterpene Acid and Phenolics from Ancient Apples of Friuli Venezia Giulia as Nutraceutical Ingredients: LC-MS Study and In Vitro Activities. Molecules, 24(6), 1-18.
dc.identifier.doi10.3390/molecules24061109en_US
dc.identifier.issn1420-3049en_US
dc.identifier.issue6en_US
dc.identifier.pmid30897820en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.3390/molecules24061109
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38361
dc.identifier.volume24en_US
dc.identifier.wosWOS:000465503800085en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofMOLECULESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAncient appleen_US
dc.subjectTriterpene acidsen_US
dc.subjectPolyphenolsen_US
dc.subjectChlorogenic aciden_US
dc.subjectLC-MSen_US
dc.subjectEnzyme inhibitionen_US
dc.titleTriterpene acid and phenolics from ancient apples of friuli venezia giulia as nutraceutical ingredients: lC-MS study and in vitro activitiesen_US
dc.typeArticleen_US

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