Vasoprotection by melatonin and quercetin in rats treated with cisplatin

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dc.contributor.authorAtalik, K. E.
dc.contributor.authorKeles, B.
dc.contributor.authorUyar, Y.
dc.contributor.authorDundar, M. A.
dc.contributor.authorOz, M.
dc.contributor.authorEsen, H. H.
dc.date.accessioned2020-03-26T18:05:33Z
dc.date.available2020-03-26T18:05:33Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCisplatin-based chemotherapy has a variety of vascular side effects. The aim of the present study was to evaluate the beneficial effect of melatonin and cisplatin on the alterations in vascular reactivity and structure of cisplatin-treated rats. Phenylephrine (PHE) and KCI-caused concentration-dependent contractions of rat aorta. Pretreatment with cisplatin increased the sensitivity but not the max response to PHE and KCl. In rats treated with melatonin or quercetin before cisplatin, the EC(50) values, but not the maximal response to both agents were significantly higher than cisplatin-treated group. Compared to the control group, cisplatin-treatment significantly reduced the luminal area of the aorta. In melatonin and quercetin-treated aortas the luminal area values were significantly higher than cisplatin-treated group. The results demonstrate for the first time that melatonin and quercetin treatment may protect the aorta in cisplatin-based chemotherapy.en_US
dc.identifier.endpage1193en_US
dc.identifier.issn0019-5189en_US
dc.identifier.issue12en_US
dc.identifier.pmid21250600en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1188en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25461
dc.identifier.volume48en_US
dc.identifier.wosWOS:000285176400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNATL INST SCIENCE COMMUNICATION-NISCAIRen_US
dc.relation.ispartofINDIAN JOURNAL OF EXPERIMENTAL BIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAortaen_US
dc.subjectCisplatinen_US
dc.subjectMelatoninen_US
dc.subjectQuercetinen_US
dc.subjectVasoprotectionen_US
dc.titleVasoprotection by melatonin and quercetin in rats treated with cisplatinen_US
dc.typeArticleen_US

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