NMR-Based Plasma Metabolomics at Set Intervals in Newborn Dairy Calves with Severe Sepsis

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dc.contributor.authorBasoglu, Abdullah
dc.contributor.authorSen, Ismail
dc.contributor.authorMeoni, Gaia
dc.contributor.authorTenori, Leonardo
dc.contributor.authorNaseri, Amir
dc.date.accessioned2020-03-26T19:54:50Z
dc.date.available2020-03-26T19:54:50Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this first study was to reveal the new potential biomarkers by a metabolomics approach in severe septic calves. Sepsis is a common cause of morbidity and mortality in newborn dairy calves. The main challenges with the use of biomarkers of sepsis in domestic animals are their availability, cost, and time required to obtain a result. Metabolomics may offer the potential to identify biomarkers that define calf sepsis in terms of combined clinical, physiological, and pathobiological abnormalities. To our knowledge, this is the first study presenting an NMR- (nuclear magnetic resonance-) based plasma metabolomics at set intervals in neonatal septic calves. Twenty neonatal dairy calves with severe sepsis and ten healthy calves were used. Hematological and biochemical health profiles were gathered in plasma samples at set intervals. Similarly, NMR spectra were acquired. All diseased animals (except one) died after 72 hours. Clinical and laboratory results were in accordance with those of severe septic animals. Multivariate analysis on NMR plasma spectra proved to be an excellent tool for faster identification of calves with severe sepsis from healthy animals. The NMR-based metabolomic profile may contribute to the better understanding of severe sepsis in newborn calves.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113O218]; ECEuropean Commission Joint Research CentreEuropean Community (EC) [653706]en_US
dc.description.sponsorshipThis work was financially supported by the Scientific and Technological Research Council of Turkey (TUBITAK, Project no. 113O218). CERM/CIRMMP center of the ESFRI Instruct is gratefully acknowledged for the NMR Access rovision financially supported by the EC Contract iNEXT no. 653706.en_US
dc.identifier.doi10.1155/2018/8016510en_US
dc.identifier.issn0962-9351en_US
dc.identifier.issn1466-1861en_US
dc.identifier.pmid29743812en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1155/2018/8016510
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36806
dc.identifier.wosWOS:000428863300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHINDAWI LTDen_US
dc.relation.ispartofMEDIATORS OF INFLAMMATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleNMR-Based Plasma Metabolomics at Set Intervals in Newborn Dairy Calves with Severe Sepsisen_US
dc.typeArticleen_US

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