Coenzyme Q10 does not prevent exercise-induced muscle damage and oxidative stress in sedentary men

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dc.contributor.authorOkudan, Nilsel
dc.contributor.authorBelviranli, Muaz
dc.contributor.authorTorlak, Savas
dc.date.accessioned2020-03-26T19:53:06Z
dc.date.available2020-03-26T19:53:06Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND: The objective of this study was to examine the effects of coenzyme Q10 (CoQ10) supplementation on exercise-induced muscle damage and oxidative stress in sedentary young men. In this study, a total of 21 sedentary and healthy young men participated. METHODS: Participants were assigned at random to a CoQ10 or a placebo group employing a double-blind method. Those in the CoQ10 group ingested 200 mg CoQ10 per day for 4 weeks. Those in the placebo group ingested the same dosage of a placebo. After the 4-week period, the same measurements and blood sampling were taken. At this point, eccentric exercise protocols (90 degrees flexion and 180 degrees extension, velocity 60 degrees/s) were instigated for all subjects in isokinetic exercise dynamometry. After exercise, blood samples were taken immediately, 24, and 48 hours later. Blood samples were analyzed for plasma CoQ10 levels, serum creatine kinase (CK) activities, myoglobin (Mb) levels, plasma total superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels. RESULTS: Plasma CoQ10 levels were higher in the CoQ10 supplemented group than in the placebo group (P<0.05). CK activities and levels of Mb increased in both groups 24 and 48 hours after exercise (P<0.05), but no significant difference between the groups was observed (P>0.05). Plasma total SOD activity and MDA levels were not significantly different in both groups 24 and 48 hours after exercise (P>0.05). CONCLUSIONS: CoQ10 supplementation does not prevent exercise induced muscle damage and oxidative stress in sedentary young men.en_US
dc.identifier.doi10.23736/S0022-4707.17.07146-8en_US
dc.identifier.endpage894en_US
dc.identifier.issn0022-4707en_US
dc.identifier.issn1827-1928en_US
dc.identifier.issue6en_US
dc.identifier.pmid28229572en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage889en_US
dc.identifier.urihttps://dx.doi.org/10.23736/S0022-4707.17.07146-8
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36406
dc.identifier.volume58en_US
dc.identifier.wosWOS:000437193100018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEDIZIONI MINERVA MEDICAen_US
dc.relation.ispartofJOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCoenzyme Q10en_US
dc.subjectMusclesen_US
dc.subjectOxidative stressen_US
dc.subjectExerciseen_US
dc.titleCoenzyme Q10 does not prevent exercise-induced muscle damage and oxidative stress in sedentary menen_US
dc.typeArticleen_US

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