Cytotoxicity of low-shrink composites with new monomer technology on bovine dental pulp-derived cells

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dc.contributor.authorYalcin, M.
dc.contributor.authorAhmetoglu, F.
dc.contributor.authorSisman, R.
dc.contributor.authorBozkurt, B. S.
dc.contributor.authorHakki, S. S.
dc.date.accessioned2020-03-26T19:01:40Z
dc.date.available2020-03-26T19:01:40Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to evaluate the cytotoxicity of four low-shrink composites with new monomer technology on the bovine dental pulp-derived cells (bDPCs). Materials and methods: Ten samples were prepared for each group composites, and the samples were immersed in 7 mL of culture medium for 72 h at 37 degrees C to extract residual monomer or cytotoxic substances. The culture medium containing the material extracts was sterile filtered for use on the cell cultures. Materials were incubated in medium with serum for 72 h. bDPCs were maintained in a medium with serum. A real-time cell analyzer was used to evaluate cell survival. After seeding 200 mL of the cell suspensions into the wells (10,000 cells/well) of the E-plate 96, bDPCs were treated with bioactive components released by the composite materials (1:1 and 1:2 dilutions) and monitored every 15 min for 50 h. Results: According to analysis of variance, there were significant differences between the cell indexes of the control and GC kalore (p < 0.05) and Bisco Reflexions (p < 0.001) groups for the 1:1 dilutions at 25 h. When evaluated at 50 h, 1:1 dilutions of GC Kalore (p < 0.01) and Bisco Reflexions (p < 0.001) reduced cell survival significantly. Conclusions: Although composites resins are being advanced, their cytotoxic effects have been proceeding till this time. However, two of the four materials tested significantly reduced cell viability when compared with control. Clinical relevance: Research should focus on the cytotoxicity of composites in addition to their mechanical properties.en_US
dc.identifier.doi10.1177/0960327113497773en_US
dc.identifier.endpage99en_US
dc.identifier.issn0960-3271en_US
dc.identifier.issn1477-0903en_US
dc.identifier.issue1en_US
dc.identifier.pmid24854397en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://dx.doi.org/10.1177/0960327113497773
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31978
dc.identifier.volume34en_US
dc.identifier.wosWOS:000346643700010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofHUMAN & EXPERIMENTAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCytotoxicityen_US
dc.subjectcompositesen_US
dc.subjectpulp-derived cellsen_US
dc.titleCytotoxicity of low-shrink composites with new monomer technology on bovine dental pulp-derived cellsen_US
dc.typeArticleen_US

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