Microwave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14 blueberry Italian cultivars

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dc.contributor.authorMollica, Adriano
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorMacedonio, Giorgia
dc.contributor.authorCarradori, Simone
dc.contributor.authorSobolev, Anatoly P.
dc.contributor.authorDe Salvador, Roberto F.
dc.contributor.authorMonti, Simona M.
dc.date.accessioned2020-03-26T19:25:06Z
dc.date.available2020-03-26T19:25:06Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe multi-component fingerprint and the biological evaluation of plant-derived material are indispensable for the pharmaceutical field, in food quality control procedures, and in all plant based products. We investigated the quantitative content of biologically active compounds (anthocyanins and chlorogenic acid) of microwave-assisted blueberry extracts from 14 different Italian cultivars, using validated high-performance liquid chromatography-photodiode array detector (HPLC-PDA) method and routinely instrument configuration. The carbonic anhydrase (CA, EC 4.2.1.1) inhibition profiles against several pharmacologically relevant CA isoforms of blueberry extracts and some bioactive compounds were also investigated. The various cultivars showed a highly variable content in anthocyanins and chlorogenic acid, and their CA inhibitory effects were also highly variable. Overall these data prove that antioxidant natural products found in blueberries may be useful for designing pharmacological agents in which various CAs are involved, e.g., antiobesity, antitumor, or anticonvulsants agents.en_US
dc.description.sponsorshipe-ALIERB Project (Regione Lazio-Dipartimento di Chimica e Tecnologie del Farmaco) [LR13/2008]en_US
dc.description.sponsorshipThe authors report that they have no conflict of interest. This work was supported by "e-ALIERB" Project (Regione Lazio LR13/2008-Dipartimento di Chimica e Tecnologie del Farmaco).en_US
dc.identifier.doi10.1080/14756366.2016.1214951en_US
dc.identifier.endpage6en_US
dc.identifier.issn1475-6366en_US
dc.identifier.issn1475-6374en_US
dc.identifier.pmid27541737en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://dx.doi.org/10.1080/14756366.2016.1214951
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33784
dc.identifier.volume31en_US
dc.identifier.wosWOS:000391904900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofJOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBlueberryen_US
dc.subjectcarbonic anhydrase inhibitorsen_US
dc.subjectcultivaren_US
dc.subjectHPLC-PDAen_US
dc.subjectmicrowave-assisted extractionen_US
dc.titleMicrowave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14 blueberry Italian cultivarsen_US
dc.typeArticleen_US

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