The cartonectin levels at different stages of chronic kidney disease and related factors

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dc.contributor.authorYavuz, Yasemin Coskun
dc.contributor.authorAltınkaynak, Konca
dc.contributor.authorSevinc, Can
dc.contributor.authorSebin, Saime Ozbek
dc.contributor.authorBaydar, Idris
dc.date.accessioned2020-03-26T20:19:22Z
dc.date.available2020-03-26T20:19:22Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Cartonectin was defined as a new adipokine released from rat and human adipocyte tissues, which is also known as CORS 26 or CTRP3 protein. Although there are several studies investigating the effects of cartonectin with obesity, anti-inflammatory mechanisms, and cardioprotective effects, there is no study about the effects of cartonectin in patients with chronic kidney disease yet. We aimed to investigate cartonectin levels in predialysis and dialysis patient groups, in other words, at different stages of chronic kidney disease, by comparing with the control group. In addition, we aimed to discuss the probable causes of the differences between the patient groups that would be determined, together with the factors that might be effective. Methods: A total of 150 patients, including 47 hemodialysis patients, 73 predialysis CKD patients, and 30 healthy individuals were enrolled in the study. Serum cartonectin levels were determined by using enzyme-linked immunosorbent assay (ELISA) method. Findings: Serum cartonectin levels were found to be significantly higher in the hemodialysis patient group compared to predialysis group and healthy individuals (p < 0.01). Furthermore, serum cartonectin levels were found to be negatively correlated with GFR, BMI, glucose, LDL, and platelet levels, whereas a positive correlation was observed with creatinine levels. Discussion: In our study, we found that the cartonectin levels increased as GFR decreased and were significantly higher in hemodialysis patients. Cartonectin is structurally closely related to adiponectin. It is remarkable that the level of cartonectin is also high in hemodialysis patients, like adiponectin.en_US
dc.identifier.citationYavuz, Y. C., Altınkaynak, K., Sevinc, C., Sebin, S. O., Baydar, I. (2019). The Cartonectin Levels At Different Stages Of Chronic Kidney Disease And Related Factors. Renal Faılure, 41,(1), 42-46.
dc.identifier.doi10.1080/0886022X.2018.1561373en_US
dc.identifier.endpage46en_US
dc.identifier.issn0886-022Xen_US
dc.identifier.issn1525-6049en_US
dc.identifier.issue1en_US
dc.identifier.pmid30732504en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage42en_US
dc.identifier.urihttps://dx.doi.org/10.1080/0886022X.2018.1561373
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38234
dc.identifier.volume41en_US
dc.identifier.wosWOS:000458146900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYavuz, Yasemin Coskun
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofRENAL FAILUREen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAdiponectinen_US
dc.subjectcartonectinen_US
dc.subjectCKDen_US
dc.subjectCTRPen_US
dc.subjecthemodialysisen_US
dc.titleThe cartonectin levels at different stages of chronic kidney disease and related factorsen_US
dc.typeReviewen_US

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