Bladder cancer invasion predictability based on preoperative neutrophil-lymphocyte ratio

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dc.contributor.authorKaynar, Mehmet
dc.contributor.authorYildirim, Mehmet Erol
dc.contributor.authorBadem, Huseyin
dc.contributor.authorCavis, Mucahit
dc.contributor.authorTekinarslan, Erdem
dc.contributor.authorIstanbulluoglu, Mustafa Okan
dc.contributor.authorKaratas, Omer Faruk
dc.date.accessioned2020-03-26T18:49:36Z
dc.date.available2020-03-26T18:49:36Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAn increased pretreatment neutrophil-lymphocyte ratio (NLR) is associated with poor prognosis in colorectal, gastric, and ovarian cancer; malignant mesothelioma; and renal cell carcinoma. The present study aims to define the predictive value of preoperative peripheral blood count NLR in non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive disease (MIBC) patients. There were in total 291 patients, 241 males and 50 females. Out of these, 156 male and 36 female patients were in the NMIBC group and 85 male and 14 female patients in the MIBC group. In the NMIBC group, 172 patients had low-grade and 20 high-grade papillary urothelial carcinoma. The mean age of the patients in the NMIBC group was 64 +/- 13, ranging from 27 to 97. The mean age of the patients in MIBC group was 70.5 +/- 10, ranging from 27 to 95. A statistically significant relation between patient ages and tumor invasiveness was determined (p = 0.023, 95 % confidence interval (CI) 63.3-66.7). The mean tumor size of the NMIBC group was 2.1 +/- 1.09 (cm) (range 0.5-8), and of MIBC group 3.6 +/- 1.5 (cm) (range 0.8-9). There was a statistically significant relation between the tumor size and invasiveness (p = 0.002, 95 % CI 2.8-4.4). In the NIMBC group, 149 (77.6 %) of them have NLR a parts per thousand currency signaEuro parts per thousand 2.5 and 43 (22.4 %) have NLR > 2.5. Also, in MIBC, 67 (67.7 %) of them have NLR a parts per thousand currency signaEuro parts per thousand 2.5 and 32 (32.3 %) have NLR > 2.5. The mean NLR in the NMIBC group was 2.4 +/- 0.1 (range 0.08-6.49, 95 % CI 1.52-2.71) and in the MIBC 2.9 +/- 0.2 (range 0.08-16.72, 95 % CI 1.67-2.97). In terms of NLR, there was a statistically significant difference between the NMIBC and MIBC groups (p = 0.028). Platelet-lymphocyte ratio (PLR) of the two groups was also analyzed. The PLR of the NMIBC group was 12.8 +/- 15.1 (range 3.38-19.1) and of the MIBC 13.6 +/- 8.78 (range 0.18-63), yet there was not any statistically significant difference (p = 0.810, 95 % CI 11.4-14.8) (Table 1). The correlation tests revealed a positive correlation between the age (r = 0.144, p = 0.024), tumor size (r = 0.193, p = 0.02), and tumor invasiveness NLR (r = 0.138, p = 0.031). NLR can be used to determine tumor invasiveness as a cost-effective, common, and simple biomarker in bladder cancer (BC).en_US
dc.identifier.doi10.1007/s13277-014-1889-xen_US
dc.identifier.endpage6605en_US
dc.identifier.issn1010-4283en_US
dc.identifier.issn1423-0380en_US
dc.identifier.issue7en_US
dc.identifier.pmid24696263en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage6601en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s13277-014-1889-x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30645
dc.identifier.volume35en_US
dc.identifier.wosWOS:000339736300055en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofTUMOR BIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBladder canceren_US
dc.subjectNeutrophil-lymphocyte ratioen_US
dc.subjectPlatelet-lymphocyte ratioen_US
dc.subjectTumor invasivenessen_US
dc.titleBladder cancer invasion predictability based on preoperative neutrophil-lymphocyte ratioen_US
dc.typeArticleen_US

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