Reduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancy

Basit Öğe Kaydı
dc.contributor.authorArtac, Hasibe
dc.contributor.authorKara, Reyhan
dc.contributor.authorGokturk, Bahar
dc.contributor.authorReisli, Ismail
dc.date.accessioned2020-03-26T18:43:08Z
dc.date.available2020-03-26T18:43:08Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe aimed to evaluate the role of the CD19 complex in the pathogenesis of transient hypogammaglobulinemia of infancy (THI) and to better characterize the subsets of memory B cells. The study population consisted of 22 male and 14 female patients with a mean age at presentation of 20 +/- A 9.9 months. The CD19 complex and B cell subsets were evaluated by flow cytometry. While the CD19 median fluorescence index (MFI) in patients with THI was significantly lower than controls (122.9 +/- A 66.7 in patients; 184.2 +/- A 39 in controls, p < 0.01), expression of CD21 and CD81 was increased (94.4 +/- A 3, 96.8 +/- A 2.5 % in patients; 91 +/- A 3.9; 94.7 +/- A 3.5 % in controls, p < 0.01 vs. p < 0.05, respectively). The expressions of switched memory B cells and IgM memory B cells were found to be reduced in THI. Considering that the CD19 complex regulates the events following antigen stimulation, the change in CD19 complex detected in THI may be related to insufficiency of antibody production.en_US
dc.description.sponsorshipScientific Research Projects of Selcuk UniversitySelcuk University [08102019]en_US
dc.description.sponsorshipThis study was supported by Scientific Research Projects of Selcuk University (Project No: 08102019).en_US
dc.identifier.doi10.1007/s10238-012-0200-yen_US
dc.identifier.endpage263en_US
dc.identifier.issn1591-8890en_US
dc.identifier.issn1591-9528en_US
dc.identifier.issue4en_US
dc.identifier.pmid22820757en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage257en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10238-012-0200-y
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29774
dc.identifier.volume13en_US
dc.identifier.wosWOS:000326830700005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER-VERLAG ITALIA SRLen_US
dc.relation.ispartofCLINICAL AND EXPERIMENTAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectTransient hypogammaglobulinemia of infancyen_US
dc.subjectCD19 complexen_US
dc.subjectMemory B cellsen_US
dc.titleReduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancyen_US
dc.typeArticleen_US

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