Assessment of Inhomogeneities of Repolarization in Patients with Systemic Lupus Erythematosus

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dc.contributor.authorAvci, Ahmet
dc.contributor.authorDemir, Kenan
dc.contributor.authorAltunkeser, Bulent Behlul
dc.contributor.authorYilmaz, Sema
dc.contributor.authorYilmaz, Ahmet
dc.contributor.authorErsecgin, Ahmet
dc.contributor.authorDemir, Tarik
dc.date.accessioned2020-03-26T18:49:29Z
dc.date.available2020-03-26T18:49:29Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: Systemic lupus erythematosus (SLE) is a chronic disease that affects many organ systems and manifests a broad spectrum of laboratory and clinical features. SLE patients have an increased risk of developing cardiovascular disease. The aim of this study was to evaluate inhomogeneities of repolarization by using T-peak-T-end (Tp-e) interval and Tp-e/QT ratio were measured from the 12-lead surface electrocardiogram (ECG) in patients with SLE. Material and method: This study included 69 SLE patients (69 females; mean age 35.8 +/- 10.2) and 57 control subjects (57 females; mean age 34.5 +/- 8.9). Transthoracic echocardiographic examination was done in all participants. QT parameters, Tp-e intervals and Tp-e/QT ratio were measured from the 12-lead ECG. These parameters were compared between groups. Results: No statistically significant difference was found between two groups in terms of basic characteristics. Diastolic function parameters were similar between the two groups (P > 0.05). In electrocardiographic parameters analysis, QT dispersion (QTd) and corrected QT dispersion (cQTd) were significantly increased in SLE patients compared the control group (49.5 +/- 16.4 ms vs. 32.8 +/- 11.7 ms and 56.7 +/- 19.5 ms vs. 36.4 +/- 13.1 ms, all P value < 0.001). Tp-e interval and Tp-e/QT ratio were also significantly higher in SLE patients (82.8 +/- 18.9 vs. 72.4 +/- 17.6 and 0.22 +/- 0.05 vs. 0.19 +/- 0.05, P = 0.002 and P = 0.001, respectively). Tp-e interval and Tp-e/QT were positively correlated with disease duration (r = 0.29, P = 0.01 and r = 0.24, P = 0.04, respectively). Conclusion: Our study revealed that QTd, cQTd, Tp-e interval and Tp-e/QT ratio increased in patients with SLE. Also, Tp-e interval and Tp-e/QT were positively correlated with disease duration.en_US
dc.identifier.doi10.1111/anec.12145en_US
dc.identifier.endpage382en_US
dc.identifier.issn1082-720Xen_US
dc.identifier.issn1542-474Xen_US
dc.identifier.issue4en_US
dc.identifier.pmid24597863en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage374en_US
dc.identifier.urihttps://dx.doi.org/10.1111/anec.12145
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30622
dc.identifier.volume19en_US
dc.identifier.wosWOS:000340092400011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofANNALS OF NONINVASIVE ELECTROCARDIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectsystemic lupus erythematosusen_US
dc.subjectarrhythmiaen_US
dc.subjectinhomogeneities of repolarizationen_US
dc.subjectTp-e intervalen_US
dc.subjectTp-e/QTen_US
dc.titleAssessment of Inhomogeneities of Repolarization in Patients with Systemic Lupus Erythematosusen_US
dc.typeArticleen_US

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