Relation of glutathione S-transferase T1, M1 and P1 genotypes and breast cancer risk

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dc.contributor.authorUnlu, Ali
dc.contributor.authorAtes, Nurcan Aras
dc.contributor.authorTamer, Lueluefer
dc.contributor.authorAtes, Cengiz
dc.date.accessioned2020-03-26T17:27:35Z
dc.date.available2020-03-26T17:27:35Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate associations between genetic variability in specific Glutathione S-transferases (GST) genes (GSTM1, GSTT1 and GSTP1) and susceptibility to breast cancer. Genotypes of blood specimen DNA were determined for 65 women with incident cases of breast cancer and 108 control subjects. Associations between specific genotypes and the development of breast cancer were examined by the use of logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Neither GSTT1 nor GSTM1 homozygous null genotype was associated with a significant increased risk of developing breast cancer. The presence of valine alleles compared to isoleucine alleles in codon 105 in GSTP1 did-not increase the risk of breast cancer development. The risk of breast cancer associated with a combined GSTT1 and GSTM1 null genotype was 3.37 (95% CI = 0.76-2.95, p = 0.115). The only significant association between increased risk of breast cancer development and GSTs polymorphsims was found when GSTT1 null, GSTM1 null and the presence of valine in GSTP1 in codon 105 were combined (p < 0.048, OR = 3.75, 95% CI = 1.01-13.90). Our findings suggest that combined genetic variability in members of the GST gene family may be associated with an increased susceptibility to breast cancer. Copyright (C) 2008 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/cbf.1490en_US
dc.identifier.endpage647en_US
dc.identifier.issn0263-6484en_US
dc.identifier.issue5en_US
dc.identifier.pmid18521819en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage643en_US
dc.identifier.urihttps://dx.doi.org/10.1002/cbf.1490
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22601
dc.identifier.volume26en_US
dc.identifier.wosWOS:000258056900014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofCELL BIOCHEMISTRY AND FUNCTIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGSTen_US
dc.subjectbreast canceren_US
dc.subjectgene polymorphismsen_US
dc.titleRelation of glutathione S-transferase T1, M1 and P1 genotypes and breast cancer risken_US
dc.typeArticleen_US

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