Comparative effects of high-dose atorvastatin versus moderate-dose rosuvastatin on lipid parameters, oxidized-LDL and inflammatory markers in ST elevation myocardial infarction

Basit Öğe Kaydı
dc.contributor.authorAydın, Meryem Ülkü
dc.contributor.authorAygül, Nazif
dc.contributor.authorAltunkeser, Bülent Behlül
dc.contributor.authorÜnlü, Ali
dc.contributor.authorTaner, Alpaslan
dc.date.accessioned2020-03-26T19:01:26Z
dc.date.available2020-03-26T19:01:26Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The important role of oxidized low density lipoprotein (oxidized-LDL) in preclinic atherosclerosis and pathophysiology of acute coronary syndromes studies have reported. Oxidation of LDL activates many inflammatory and atherogenic pathways and plays a pivotal role in atherosclerosis. Our aim in this study is to compare the effects of 80 mg daily dose of atorvastatin and 20 mg daily dose of rosuvastatin on lipid profiles and the levels of oxidized-LDL and inflammatory markers in ST elevation myocardial infarction (STEMI). Methods: One hundred and twenty patients with STEMI were enrolled in this study. The patients were randomly assigned to receive atorvastatin (80 mg/day) or rosuvastatin (20 mg/day) by using a ratio of 1: 1 after revascularization. The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), LDL-C, apolipoprotein B and apolipoprotein A were compared between groups after 4-week therapy. The values of oxidized-LDL, tumor necrosis factor receptor 1 and 2, Interleukin-6 and hs-CRP were also compared between groups. The Student's t test was used to detect absolute and percent changes between groups, and p < 0.05 was considered as statistically significant for all tests. Results: After treatment in both treatment groups LDL-C, oxidized-LDL, hs-CRP, tumor necrosis factor receptor 1 and 2, Interleukin-6 values significantly decreased according to baseline. The only difference was in HDL-C levels. HDL-C slightly decreased in atorvastatin group while it increased in the rosuvastatin group compared baseline ( 1.4 +/- 8.9 mg/dl vs 2.0 +/- 9.4 mg/dl, p = 0.04). Conclusion: We reported that both statin treatment regiments have comparable effects on LDL-C, oxidized-LDL and inflammatory markers. Moreover, it was observed that rosuvastatin was more effective in terms of ability to increase HDL-C level. Based on these findings, 20 mg daily dose of rosuvastatin may be an alternative to 80 mg daily dose of atorvastatin in patients with acute coronary syndrome. (C) 2015 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific Research Project Coordinator of Selcuk University (BAP)Selcuk University [07102018]en_US
dc.description.sponsorshipThis study was supported by Scientific Research Project Coordinator of Selcuk University (BAP#07102018) and the founding source did not involve in study design, in the collection, analysis, and interpretation of data; in the writing of the report; in the decision to submit the article for publication.en_US
dc.identifier.doi10.1016/j.atherosclerosis.2015.02.003en_US
dc.identifier.endpage443en_US
dc.identifier.issn0021-9150en_US
dc.identifier.issn1879-1484en_US
dc.identifier.issue2en_US
dc.identifier.pmid25697576en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage439en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.atherosclerosis.2015.02.003
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31944
dc.identifier.volume239en_US
dc.identifier.wosWOS:000351061600023en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER IRELAND LTDen_US
dc.relation.ispartofATHEROSCLEROSISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAtorvastatinen_US
dc.subjectRosuvastatinen_US
dc.subjectLipid parametersen_US
dc.subjectOxidized-LDLen_US
dc.subjectInflammatory markersen_US
dc.subjectST segment elevation myocardial infarctionen_US
dc.titleComparative effects of high-dose atorvastatin versus moderate-dose rosuvastatin on lipid parameters, oxidized-LDL and inflammatory markers in ST elevation myocardial infarctionen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu