Effect of preoperative atorvastatin therapy on paraoxonase activity and oxidative stress after coronary artery bypass grafting

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dc.contributor.authorKurban, Sevil
dc.contributor.authorMehmetoglu, Idris
dc.contributor.authorEge, Erdal
dc.date.accessioned2020-03-26T17:38:22Z
dc.date.available2020-03-26T17:38:22Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to examine the influence of preoperative atorvastatin therapy on oxidative stress in coronary artery bypass grafting (CABG) patients. Forty patients who underwent elective CABG were enrolled into the study. Of these patients, 20 received atorvastatin (Group I) for 15 days prior to surgery and 20 patients did not use any antihyperlipidemic agents preoperatively (Group II). Serum paraoxonase 1 (PON1) and arylesterase activities, and total antioxidant status (TAS) and total oxidant status (TOS) were measured before surgery and at 1, 6 and 24 hours after the operation. Paraoxonase 1 and arylesterase activities (p<0.001) and TAS levels (p<0.001 for 1(st) hour and p<0.05 for 6th hour) in Group II were significantly reduced at the 1(st) and 6(th) hours after the operation, whereas the activities of the enzymes (p<0.01) and TAS levels (p<0.05) were significantly reduced only at the 1(st) hour after the operation in Group I. The total oxidant status of both groups was significantly increased at the 1(st) hour after operation (p<0.05 for Group I and p<0.01 for Group II). In conclusion, 15 days of preoperative atorvastatin therapy does not significantly change either the serum PON1 activity or the oxidative stress after CABG.en_US
dc.identifier.doi10.1177/0267659109350240en_US
dc.identifier.endpage276en_US
dc.identifier.issn0267-6591en_US
dc.identifier.issn1477-111Xen_US
dc.identifier.issue4en_US
dc.identifier.pmid19843623en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage271en_US
dc.identifier.urihttps://dx.doi.org/10.1177/0267659109350240
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23458
dc.identifier.volume24en_US
dc.identifier.wosWOS:000272192200009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofPERFUSION-UKen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectatorvastatinen_US
dc.subjectcoronary artery bypass graftingen_US
dc.subjectparaoxonaseen_US
dc.subjecttotal antioxidant statusen_US
dc.subjecttotal oxidant statusen_US
dc.titleEffect of preoperative atorvastatin therapy on paraoxonase activity and oxidative stress after coronary artery bypass graftingen_US
dc.typeArticleen_US

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