Protective effects of curcumin supplementation on intestinal ischemia reperfusion injury

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dc.contributor.authorOkudan, N.
dc.contributor.authorBelviranli, M.
dc.contributor.authorGokbel, H.
dc.contributor.authorOz, M.
dc.contributor.authorKumak, A.
dc.date.accessioned2020-03-26T18:43:02Z
dc.date.available2020-03-26T18:43:02Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effects curcumin on inflammation and oxidative stress markers in the intestinal ischemia reperfusion (IIR) injury induced rats. Rats were divided into four groups: sham (S), intestinal IR (IIR), curcumin plus sham (CS), and curcumin plus intestinal IR (CIIR). Curcumin was given 200 mg kg(-1) for 20 days. IIR was produced by 45 min of intestinal ischemia followed by a 120 min of reperfusion. Although interleukin-6 levels tended to increase in IIR group tumor necrosis factor-alpha levels were not different. Intestinal myeloperoxidase activity in CS group was lower than IIR group. In intestine and heart tissues, malondialdehyde levels in CS and CIIR groups were lower than S and IIR groups. Superoxide dismutase activity in CIIR group was higher than IIR group in intestine and lung tissues. Curcumin has a protective role against ischemia reperfusion injury. (C) 2013 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.phymed.2013.03.022en_US
dc.identifier.endpage848en_US
dc.identifier.issn0944-7113en_US
dc.identifier.issue10en_US
dc.identifier.pmid23647746en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage844en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.phymed.2013.03.022
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29757
dc.identifier.volume20en_US
dc.identifier.wosWOS:000323140200011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER GMBH, URBAN & FISCHER VERLAGen_US
dc.relation.ispartofPHYTOMEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCurcuminen_US
dc.subjectIntestinal ischemia reperfusionen_US
dc.subjectLungen_US
dc.subjectHearten_US
dc.subjectOxidative stressen_US
dc.titleProtective effects of curcumin supplementation on intestinal ischemia reperfusion injuryen_US
dc.typeArticleen_US

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