Lack of association between the glutathione-s-transferase genes (GSTT1 and GSTM1) and nasal polyposis

dc.contributor.authorArbağ, Hamdi
dc.contributor.authorÇora, Tülin
dc.contributor.authorAcar, Hasan
dc.contributor.authorÖztürk, Kayhan
dc.contributor.authorSarı, Fatih
dc.contributor.authorUlusoy, Bülent
dc.date.accessioned2020-03-26T17:03:48Z
dc.date.available2020-03-26T17:03:48Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: To evaluate the glutation-S-transferase (GST) polymorphisms (GSTM1 and GSTT1) in nasal polyposis (NP). Methods: The study population consisted of 102 unrelated healthy individuals and 98 patients with NP (67 without asthma, 31 with asthma). Genotyping of the polymorphism in the GSTM1 and GSTT1 genes was performed using the multiplex polymerase chain reaction (PCR)-based method. Results: GSTM1 and GSTT1 null-genotypes were found in 46.1% and 23.5% of the controls, and in 43.9% and 33.7% of the NP patients, respectively. These differences were not significant (for GSTM1 null odds ratio (OR) = 0.92; 95% confidence interval (CI) = 0.52-1.6 and for GSTT1, OR = 1.65; 9.5% CI = 0.89-3.07). Although no significant difference for combined GSTM1 and GSTT1 null genotypes between control (8.8%) and NP patients (17.30%) was found, there was a 2.16-fold increased proportion in the NP with the combined GSTM1-null and GSTT1-null genotype (OR = 2.16; 95% CI = 0.91-5.13). Conclusion: These results suggest that there is lack of association between GSTM1 and GSTT1 polymorphisms and NP. The GSTM1 or GSTT1 polymorphisms had also no relevant developing effect on NP patients without or with asthma.en_US
dc.identifier.endpage18en_US
dc.identifier.issn0300-0729en_US
dc.identifier.issue1en_US
dc.identifier.pmid16550944en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage14en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20561
dc.identifier.volume44en_US
dc.identifier.wosWOS:000236367500004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINT RHINOLOGIC SOCen_US
dc.relation.ispartofRHINOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGlutation-S-transferase genesen_US
dc.subjectPolymorphismen_US
dc.subjectNasal polyposisen_US
dc.subjectGenotypeen_US
dc.titleLack of association between the glutathione-s-transferase genes (GSTT1 and GSTM1) and nasal polyposisen_US
dc.typeArticleen_US

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