Increased micronucleus frequency in rat bone marrow after acrylamide treatment

Basit Öğe Kaydı
dc.contributor.authorYener, Y.
dc.contributor.authorDikmenli, M.
dc.date.accessioned2020-03-26T17:38:57Z
dc.date.available2020-03-26T17:38:57Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study was performed to investigate whether acrylamide (AA), occured during cooking carbohydrate-rich foods at high temperature, increased the frequency of micronucleated polychromatic erythrocytes (MNPCEs) in rat bone marrow. For this purpose AA, dissolved in distilled water, was administered to 8-week old male Sprague Dawley rats at single oral doses of 0, 125,150 or 175 mg/kg b.w. After 48 h from AA treatment, the bone marrow samples were analysed for the frequency of MNPCEs. The cytotoxic effect of AA on bone marrow was also tested by assessing polychromatic erythrocyte/normochromatic erythrocyte (PCE/NCE) ratio. It was found that all three doses applied significantly increased the frequency of MNPCEs and this increase was 3.75-fold in rats given the highest administered dose of AA. In addition AA decreased the PCE/NCE ratio, which is indicative of bone marrow cytotoxicity when compared to the control group. This study displayed that AA increased the formation of micronuclei in polychromatic erythrocytes (PCEs) of rat bone marrow and this increase might have resulted from administrating the high dose level of AA to rats by gavage instead of by i.p. injection. (C) 2009 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [06101002]en_US
dc.description.sponsorshipWe express our thanks to Scientific Investigation Project to Coordinate of Selcuk University (Project No: 06101002) for financial support.en_US
dc.identifier.doi10.1016/j.fct.2009.05.037en_US
dc.identifier.endpage2123en_US
dc.identifier.issn0278-6915en_US
dc.identifier.issn1873-6351en_US
dc.identifier.issue8en_US
dc.identifier.pmid19500643en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2120en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.fct.2009.05.037
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23611
dc.identifier.volume47en_US
dc.identifier.wosWOS:000269100700059en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofFOOD AND CHEMICAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAcrylamideen_US
dc.subjectRaten_US
dc.subjectMicronucleusen_US
dc.subjectGenotoxicityen_US
dc.subjectCytotoxicityen_US
dc.titleIncreased micronucleus frequency in rat bone marrow after acrylamide treatmenten_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu