Expression of Fas and Fas-ligand and analysis of argyrophilic nucleolar organizer regions in squamous cell carcinoma: relationships with tumor stage and grade, and apoptosis

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dc.contributor.authorGuler, N
dc.contributor.authorUckan, S
dc.contributor.authorCelik, I
dc.contributor.authorOznurlu, Y
dc.contributor.authorUckan, D
dc.date.accessioned2020-03-26T16:57:12Z
dc.date.available2020-03-26T16:57:12Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate whether levels of Fas and Fas-ligand (Fas-L) expression in oral and oropharyngeal squamous cell carcinomas (SCCs) are associated with tumor stage and grade, and to assess whether parameters related to argyrophilic nucleolar organizer regions (AgNORs) correlate with apoptosis in SCC cells and adjacent normal epithelium. Fifty-two specimens taken from the tumoral and neighboring normal tissues of 26 patients with oral and oropharyngeal SCC were analyzed for Fas/Fas-L expression, and 24 specimens from 12 patients for AgNOR parameters. Seventeen (65%) of the tumors were Fas and/or Fas-L-positive (by immunohistochemistry). A significant positive correlation was found between Fas/FasL expression and clinical tumor stage (P < 0.01). Mean AgNOR number per nucleus, AgNOR size and the percentage area of each nucleus occupied by AgNORs (percent of nuclear area) were significantly increased in the SCC cells (4.49 +/- 1.28, 4.48 +/- 1.42, 5.56 +/- 1.22, respectively) when compared with the control neighboring squamous epithelial cells (2.58 +/- 0.61, 1.64 +/- 0.59 and 4.35 +/- 0.62%, respectively) (P < 0.01). A significant positive correlation was found between the AgNOR parameters and Fas/ Fas-L expression as apoptotic markers in the tumoral cells of SCC (P < 0.05). There was also a significant positive correlation between the AgNOR parameters and the grading of tumors (P < 0.05). In conclusion, AgNOR count was a strong proliferation marker in patients with SCC, and Fas and Fas-L staining was useful in tumor grading.en_US
dc.identifier.doi10.1016/j.ijom.2005.03.006en_US
dc.identifier.endpage906en_US
dc.identifier.issn0901-5027en_US
dc.identifier.issn1399-0020en_US
dc.identifier.issue8en_US
dc.identifier.pmid15907374en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage900en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijom.2005.03.006
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19740
dc.identifier.volume34en_US
dc.identifier.wosWOS:000233387500012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCHURCHILL LIVINGSTONEen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleExpression of Fas and Fas-ligand and analysis of argyrophilic nucleolar organizer regions in squamous cell carcinoma: relationships with tumor stage and grade, and apoptosisen_US
dc.typeArticleen_US

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