A comparison of a 5% potassium hydroxide solution with a 5-fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open-label clinical trial

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dc.contributor.authorIşık, Selda
dc.contributor.authorKoca, Rafet
dc.contributor.authorSarıcı, Gülben
dc.contributor.authorAltınyazar, Hilmi Cevdet
dc.date.accessioned2020-03-26T18:49:07Z
dc.date.available2020-03-26T18:49:07Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAnogenital warts are caused by human papillomavirus (HPV), over 30 types of which are infectious for the anogenital tract. Without treatment, warts may regress spontaneously, remain unchanged, or increase in number and size. This study compared the efficacy of a topical 5% potassium hydroxide (KOH) solution with that of a topical 0.5% 5-fluorouracil (5-FU) and 10% salicylic acid (SA) combination in the treatment of anogenital warts. Sixty patients were randomly assigned to receive topical KOH or 5-FU + SA. Both groups demonstrated a significant decrease in numbers of lesions (P < 0.05), but this difference was not significant at week 12 (P > 0.05). The mean number of lesions decreased from baseline to week 12 from 17.03 +/- 12.64 to 3.73 +/- 7.30 and from 16.13 +/- 12.97 to 3.10 +/- 4.90 in the KOH and 5-FU + SA groups, respectively (P < 0.001). Excellent clearance was achieved by 70.0 and 76.7% of patients in the KOH and 5-FU + SA groups, respectively. Marked improvement was seen in 13.3 and 20.0% of patients in the KOH and 5-FU + SA groups, respectively. At week 16, relapse was observed in two patients in the KOH group and three in the 5-FU + SA group (P > 0.05). No serious adverse events were reported. Neither treatment was more efficacious. Safety and ease of application are important goals in treatments for anogenital warts. A 5% KOH solution is a promising alternative treatment because it is effective and inexpensive and causes minimal side effects.en_US
dc.identifier.doi10.1111/ijd.12505en_US
dc.identifier.endpage1150en_US
dc.identifier.issn0011-9059en_US
dc.identifier.issn1365-4632en_US
dc.identifier.issue9en_US
dc.identifier.pmid25039244en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1145en_US
dc.identifier.urihttps://dx.doi.org/10.1111/ijd.12505
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30530
dc.identifier.volume53en_US
dc.identifier.wosWOS:000340575100032en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF DERMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleA comparison of a 5% potassium hydroxide solution with a 5-fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open-label clinical trialen_US
dc.typeArticleen_US

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