Effects of Grape Seed Polyphenols on Oxidative Damage in Liver Tissue of Acutely and Chronically Exercised Rats

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dc.contributor.authorBelviranli, Muaz
dc.contributor.authorGokbel, Hakki
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorBuyukbas, Sadik
dc.date.accessioned2020-03-26T18:41:43Z
dc.date.available2020-03-26T18:41:43Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe objective of the present study was to investigate the effects of grape seed extract (GSE) supplementation on oxidative stress and antioxidant defense markers in liver tissue of acutely and chronically exercised rats. Rats were randomly assigned to six groups: Control (C), Control Chronic Exercise (CE), Control Acute Exercise (AE), GSE-supplemented Control (GC), GSE-supplemented Chronic Exercise(GCE) and GSE-supplemented Acute Exercise (GAE). Rats in the chronic exercise groups were subjected to a six-week treadmill running and in the acute exercise groups performed an exhaustive running. Rats in the GSE supplemented groups received GSE (100 mg.kg1.day1) in drinking water for 6 weeks. Liver tissues of the rats were taken for the analysis of malondialdehyde (MDA), nitric oxide (NO) levels and total antioxidant activity (AOA) and xanthine oxidase (XO) activities. MDA levels decreased with GSE supplementation in control groups but increased in acute and chronic exercise groups compared to their non-supplemented control. NO levels increased with GSE supplementation. XO activities were higher in AE group compared to the CE group. AOA decreased with GSE supplementation. In conclusion, while acute exercise triggers oxidative stress, chronic exercise has protective role against oxidative stress. GSE has a limited antioxidant effect on exercise-induced oxidative stress in liver tissue. Copyright (c) 2012 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/ptr.4772en_US
dc.identifier.endpage677en_US
dc.identifier.issn0951-418Xen_US
dc.identifier.issn1099-1573en_US
dc.identifier.issue5en_US
dc.identifier.pmid22745005en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage672en_US
dc.identifier.urihttps://dx.doi.org/10.1002/ptr.4772
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29446
dc.identifier.volume27en_US
dc.identifier.wosWOS:000318031500006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofPHYTOTHERAPY RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectgrape seed extracten_US
dc.subjectexerciseen_US
dc.subjectoxidative stressen_US
dc.subjectliveren_US
dc.titleEffects of Grape Seed Polyphenols on Oxidative Damage in Liver Tissue of Acutely and Chronically Exercised Ratsen_US
dc.typeArticleen_US

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