The protective effect of L-carnitine against hippocampal damage due to experimental formaldehyde intoxication in rats

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dc.contributor.authorOzmen, E.
dc.contributor.authorOzsoy, S. Y.
dc.contributor.authorDonmez, N.
dc.contributor.authorOzsoy, B.
dc.contributor.authorYumusak, N.
dc.date.accessioned2020-03-26T18:58:39Z
dc.date.available2020-03-26T18:58:39Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe investigated the protective effects of L-carnitine on hippocampus tissue damage in rats during experimental formaldehyde (FA) intoxication. Male Wistar albino rats were assigned into four groups: (1) control (C), (2) formaldehyde (FA), (3) formaldehyde + 0.5 g/kg of L-carnitine (FA + 0.5 LC) (4) formaldehyde + 1 g/kg L-carnitine (FA + 1 LC). At the end of the 14 day trial period, animals were sacrificed by decapitation under anesthesia. The hippocampus tissue samples were extracted to measure MDA, GSH and SOD activity. Neuronal degeneration was assessed based on histopathological (hematoxylin and eosin) and immunohistochemical (anti-ubiquitin) examination. To detect oxidative stress, specimens were reacted with anti-Cu/Zn-SOD antibody. After administering L-carnitine with FA to the animals, the activities of SOD and GSH increased, but the levels of MDA decreased in hippocampus tissue. Neuronal degeneration was observed in the FA group. L-carnitine administration reduced neuronal degeneration and histological structure was similar to controls. After FA application, degenerated hippocampus neurons were stained with anti-ubiquitin and Cu/Zn-SOD antibodies; weakly positive staining was observed in L-carnitine-treated groups. L-carnitine may be useful for preventing oxidative damage in the hippocampus tissue due to formaldehyde intoxication.en_US
dc.description.sponsorshipproject Mustafa Kemal University Scientific Research ProjectsMustafa Kemal University [1005 M 0112]en_US
dc.description.sponsorshipThis research was supported by project Mustafa Kemal University Scientific Research Projects (1005 M 0112).en_US
dc.identifier.doi10.3109/10520295.2013.855818en_US
dc.identifier.endpage341en_US
dc.identifier.issn1052-0295en_US
dc.identifier.issn1473-7760en_US
dc.identifier.issue5en_US
dc.identifier.pmid24279609en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage336en_US
dc.identifier.urihttps://dx.doi.org/10.3109/10520295.2013.855818
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31220
dc.identifier.volume89en_US
dc.identifier.wosWOS:000337900500003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINFORMA HEALTHCAREen_US
dc.relation.ispartofBIOTECHNIC & HISTOCHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectformaldehyde intoxicationen_US
dc.subjecthippocampusen_US
dc.subjecthistopathologyen_US
dc.subjectimmunohistochemistryen_US
dc.subjectL-carnitineen_US
dc.subjectoxidative damageen_US
dc.subjectraten_US
dc.titleThe protective effect of L-carnitine against hippocampal damage due to experimental formaldehyde intoxication in ratsen_US
dc.typeArticleen_US

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