Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1 alpha/FNDC5/BDNF Pathway

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dc.contributor.authorBelviranli, Muaz
dc.contributor.authorOkudan, Nilsel
dc.date.accessioned2020-03-26T19:53:54Z
dc.date.available2020-03-26T19:53:54Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis study aimed to determine the effect of exercise training on cognitive functioning, and hippocampal PGC-1 alpha, FNDC5, BDNF, and other cognition-related gene and protein expression in rats. Rats were divided into 4 groups based on age [3 months (young) vs. 20 months (aged)] and training status (control vs. exercise training). The rats that exercised voluntarily performed exercise training for 90 days, and then all the rats underwent several methods of behavioral assessment. Locomotor activity and spatial memory were lower but anxiety scores were higher in the aged control rats, than in the young control, young exercised, and aged exercised rats (P < 0.05). Hippocampal BDNF, FNDC5, PGC-1 alpha, mTOR, ARC, cF-OS, ERK, SIRT, and FOXO expressions were lower, but NF-kappa B expressions were higher in the aged control rats than in the young control, young exercised, and aged exercised rats (P < 0.05). Similarly, hippocampal BDNF and FNDC5 protein expression were lower in the aged control rats than in the young control, young exercised, and aged exercised rats (P < 0.05). These findings show that aging-induced cognitive dysfunction is associated with a decrease in hippocampal expression of PGC-1 alpha, FNDC5, and BDNF, and that exercise training might improve cognitive functioning via activation of these genes and proteins.en_US
dc.description.sponsorshipSelcuk University Scientific Research and Project Committee [15401171]en_US
dc.description.sponsorshipThis study was supported by the Selcuk University Scientific Research and Project Committee (project number: 15401171). The authors would like to thank Scott Evans for English language editing.en_US
dc.identifier.doi10.1007/s12017-018-8500-3en_US
dc.identifier.endpage400en_US
dc.identifier.issn1535-1084en_US
dc.identifier.issn1559-1174en_US
dc.identifier.issue3en_US
dc.identifier.pmid29971668en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage386en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s12017-018-8500-3
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36619
dc.identifier.volume20en_US
dc.identifier.wosWOS:000441020000008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHUMANA PRESS INCen_US
dc.relation.ispartofNEUROMOLECULAR MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAgingen_US
dc.subjectExerciseen_US
dc.subjectBDNFen_US
dc.subjectFNDC5en_US
dc.subjectIrisinen_US
dc.subjectCognitionen_US
dc.titleExercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1 alpha/FNDC5/BDNF Pathwayen_US
dc.typeArticleen_US

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