Cytotoxic and Enzyme Inhibitory Potential of Two Potentilla species (P-speciosa L. and P-reptans Willd.) and Their Chemical Composition

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dc.contributor.authorUysal, Şengül
dc.contributor.authorZengin, Gökhan
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorBahadori, Mir B.
dc.contributor.authorMocan, Andrei
dc.contributor.authorBellagamba, Giuseppe
dc.contributor.authorDe Luca, Elisa
dc.date.accessioned2020-03-26T19:34:43Z
dc.date.available2020-03-26T19:34:43Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this work, the biological and chemical fingerprints of three extracts (ethyl acetate, methanol, and water) from two Potentilla species (Potentilla reptans and P. speciosa) were investigated. Antioxidant, enzyme inhibitory, and cytotoxic activities were performed for the biological fingerprint. For the chemical characterization, total bioactive components, and individual phenolic components were determined using photometric and HPLC methods, respectively. The main identified phenolic compounds in these extracts were rutin and catechin. Methanol and water extracts contained the highest total phenolic and flavonoid content. The results of antioxidant assays showed that methanol and water extracts displayed higher antioxidant activity compared to the ethyl acetate extract. Generally, methanol and water extracts exhibited higher biological activities correlated with higher levels the bioactive components. For P. speciosa, the methanol extract exhibited the highest enzyme inhibitory activity (except BChE inhibitory activity). P. reptans exhibited also high antiproliferative activity against MCF-7 cells whilst P. speciosa had weak to moderate activity against both of A549 and MCF-7 cell lines. The results suggest that Potentilla species could be potential candidates for developing new phyto-pharmaceuticals and functional ingredients.en_US
dc.identifier.doi10.3389/fphar.2017.00290en_US
dc.identifier.issn1663-9812en_US
dc.identifier.pmid28588492en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.3389/fphar.2017.00290
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34942
dc.identifier.volume8en_US
dc.identifier.wosWOS:000402264000002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFRONTIERS MEDIA SAen_US
dc.relation.ispartofFRONTIERS IN PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPotentilla reptansen_US
dc.subjectP. speciosaen_US
dc.subjectantioxidant activityen_US
dc.subjectenzyme inhibitory activityen_US
dc.subjectcytotoxicen_US
dc.titleCytotoxic and Enzyme Inhibitory Potential of Two Potentilla species (P-speciosa L. and P-reptans Willd.) and Their Chemical Compositionen_US
dc.typeArticleen_US

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